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Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Pipeline Review, H1 2019

Summary

Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) pipeline Target constitutes close to 25 molecules. Out of which approximately 23 molecules are developed by companies and remaining by the universities/institutes. The latest report Tumor Necrosis Factor Receptor Superfamily Member 5 - Pipeline Review, H1 2019, outlays comprehensive information on the Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Tumor Necrosis Factor Receptor Superfamily Member 5 is a member of the TNF-receptor superfamily. This protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. The molecules developed by companies in Phase II, Phase I, Preclinical and Discovery stages are 6, 6, 7 and 4 respectively. Similarly, the universities portfolio in Preclinical stages comprises 2 molecules, respectively.

Report covers products from therapy areas Oncology, Immunology, Gastrointestinal, Genito Urinary System And Sex Hormones, Central Nervous System, Dermatology, Hormonal Disorders and Metabolic Disorders which include indications Solid Tumor, Melanoma, Non-Small Cell Lung Cancer, Pancreatic Cancer, Gastric Cancer, Head And Neck Cancer Squamous Cell Carcinoma, Kidney Transplant Rejection, Lymphoma, Ovarian Cancer, Bladder Cancer, Breast Cancer, Crohn's Disease (Regional Enteritis), Esophageal Cancer, Lupus Nephritis, Metastatic Breast Cancer, Metastatic Colorectal Cancer, Metastatic Melanoma, Metastatic Ovarian Cancer, Metastatic Pancreatic Cancer, Myasthenia Gravis, Adenocarcinoma Of The Gastroesophageal Junction, Anaplastic Astrocytoma, Astrocytoma, Bile Duct Cancer (Cholangiocarcinoma), Central Nervous System (CNS) Tumor, Cervical Cancer, Colorectal Cancer, Focal Segmental Glomerulosclerosis (FSGS), Glioblastoma Multiforme (GBM), Glioma, Gliosarcoma, Graft Versus Host Disease (GVHD), Graves Diseases, Head And Neck Cancer, Heart Transplant Rejection, Hepatic (Liver) Tumor, Hidradenitis Suppurativa, Hyperthyroidism, Kidney Cancer (Renal Cell Cancer), Leiomyosarcoma, Liposarcoma, Liver Transplant Rejection, Malignant Mesothelioma, Membranous Glomerulonephritis, Metastatic Adenocarcinoma of The Pancreas, Metastatic Transitional (Urothelial) Tract Cancer, Multiple Sclerosis, Pancreatic Ductal Adenocarcinoma, Pancreatic Islet Transplant Rejection, Pediatric Diffuse Intrinsic Pontine Glioma, Pemphigus, Primary Biliary Cirrhosis, Prostate Cancer, Renal Cell Carcinoma, Rheumatoid Arthritis, Sicca Syndrome (Sjogren), Soft Tissue Sarcoma, Squamous Non-Small Cell Lung Cancer, Transitional Cell Carcinoma (Urothelial Cell Carcinoma), Type 1 Diabetes (Juvenile Diabetes) and Ulcerative Colitis.

Furthermore, this report also reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40)
- The report reviews Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) targeted therapeutics and enlists all their major and minor projects
- The report assesses Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope


Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Overview

              Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Therapeutics Development

                Products under Development by Stage of Development

                  Products under Development by Therapy Area

                    Products under Development by Indication

                      Products under Development by Companies

                        Products under Development by Universities/Institutes

                          Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Therapeutics Assessment

                            Assessment by Mechanism of Action

                              Assessment by Route of Administration

                                Assessment by Molecule Type

                                  Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Companies Involved in Therapeutics Development

                                    AbbVie Inc

                                      Apexigen Inc

                                        Apogenix AG

                                          Avacta Life Sciences Ltd

                                            BioNTech SE

                                              Boehringer Ingelheim GmbH

                                                Celldex Therapeutics Inc

                                                  Denceptor Therapeutics Ltd

                                                    F. Hoffmann-La Roche Ltd

                                                      Johnson & Johnson

                                                        Kyowa Hakko Kirin Co Ltd

                                                          MedImmune LLC

                                                            Molecular Partners AG

                                                              Novartis AG

                                                                Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Drug Profiles

                                                                  ABBV-428 - Drug Profile

                                                                    Product Description

                                                                      Mechanism Of Action

                                                                        R&D Progress

                                                                          ABBV-927 - Drug Profile

                                                                            Product Description

                                                                              Mechanism Of Action

                                                                                R&D Progress

                                                                                  APG-1233 - Drug Profile

                                                                                    Product Description

                                                                                      Mechanism Of Action

                                                                                        R&D Progress

                                                                                          APX-005M - Drug Profile

                                                                                            Product Description

                                                                                              Mechanism Of Action

                                                                                                R&D Progress

                                                                                                  AVA-023 - Drug Profile

                                                                                                    Product Description

                                                                                                      Mechanism Of Action

                                                                                                        R&D Progress

                                                                                                          BI-655064 - Drug Profile

                                                                                                            Product Description

                                                                                                              Mechanism Of Action

                                                                                                                R&D Progress

                                                                                                                  Bispecific Monoclonal Antibody to Agonize CD40 and 4-1BB for Solid Tumors - Drug Profile

                                                                                                                    Product Description

                                                                                                                      Mechanism Of Action

                                                                                                                        R&D Progress

                                                                                                                          Bispecific Monoclonal Antibody to Agonize CD40 for Oncology - Drug Profile

                                                                                                                            Product Description

                                                                                                                              Mechanism Of Action

                                                                                                                                R&D Progress

                                                                                                                                  bleselumab - Drug Profile

                                                                                                                                    Product Description

                                                                                                                                      Mechanism Of Action

                                                                                                                                        R&D Progress

                                                                                                                                          CDX-1140 - Drug Profile

                                                                                                                                            Product Description

                                                                                                                                              Mechanism Of Action

                                                                                                                                                R&D Progress

                                                                                                                                                  DNP-005 - Drug Profile

                                                                                                                                                    Product Description

                                                                                                                                                      Mechanism Of Action

                                                                                                                                                        R&D Progress

                                                                                                                                                          FFP-104 - Drug Profile

                                                                                                                                                            Product Description

                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                R&D Progress

                                                                                                                                                                  iscalimab - Drug Profile

                                                                                                                                                                    Product Description

                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                        R&D Progress

                                                                                                                                                                          JNJ-7107 - Drug Profile

                                                                                                                                                                            Product Description

                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                R&D Progress

                                                                                                                                                                                  KGYY-15 - Drug Profile

                                                                                                                                                                                    Product Description

                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                          KPL-404 - Drug Profile

                                                                                                                                                                                            Product Description

                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                  MEDI-5083 - Drug Profile

                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                          MegaCD40L - Drug Profile

                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                  Monoclonal Antibodies to Agonize CD40 and Antagonize FCGR2B for B-cell Lymphoma and Melanoma - Drug Profile

                                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                                          Monoclonal Antibody Conjugate to Target CD40 for Pancreatic Cancer - Drug Profile

                                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                                  Recombinant Protein to Target FAP and CD40 for Oncology - Drug Profile

                                                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                                                          selicrelumab - Drug Profile

                                                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                                                  selicrelumab + vanucizumab - Drug Profile

                                                                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                                                                          UltraCD40L - Drug Profile

                                                                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                                                                  Vaccine to Target CD40 for Membranous Glomerulonephritis - Drug Profile

                                                                                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                                                                                          Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Dormant Products

                                                                                                                                                                                                                                                                            Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Discontinued Products

                                                                                                                                                                                                                                                                              Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Product Development Milestones

                                                                                                                                                                                                                                                                                Featured News & Press Releases

                                                                                                                                                                                                                                                                                  Jan 29, 2019: Alligator Bioscience publishes clinical phase I data for ADC-1013 in the International Journal of Cancer

                                                                                                                                                                                                                                                                                    Nov 09, 2018: Celldex presents promising interim data from phase 1 study of differentiated CD40 agonist CDX-1140 at the Society for Immunotherapy of Cancer’s 33rd Annual Meeting

                                                                                                                                                                                                                                                                                      Nov 06, 2018: Molecular Partners to present data on DARPin immuno-oncology compound FAP x CD40 at upcoming scientific conferences

                                                                                                                                                                                                                                                                                        Oct 11, 2018: Preclinical efficacy data of Apogenix HERA-CD40L published in Journal of Immunotherapy

                                                                                                                                                                                                                                                                                          May 18, 2018: Apexigen Expands Leadership Team with Appointment of Frances Rena Bahjat, Vice President, Discovery Research

                                                                                                                                                                                                                                                                                            Apr 20, 2018: Celldex Therapeutics presents data on CDX-1140 at AACR Annual Meeting 2018

                                                                                                                                                                                                                                                                                              Jan 03, 2018: Alligator Bioscience to receive USD 6 million milestone payment from Janssen coupled to the decision to initiate combination trial with ADC-1013

                                                                                                                                                                                                                                                                                                Nov 30, 2017: Celldex Therapeutics Initiates Phase 1 Study of New Product Candidate CDX-1140 in Solid Tumors

                                                                                                                                                                                                                                                                                                  Nov 07, 2017: Results from Alligator Biosciences clinical phase I study support further clinical development of ADC-1013

                                                                                                                                                                                                                                                                                                    Oct 31, 2017: Apexigen Announces Late-Breaking Oral Presentation for Immune Activating Antibody APX005M at the 2017 Society for Immunotherapy of Cancer Annual Meeting

                                                                                                                                                                                                                                                                                                      Oct 25, 2017: Apexigen Announces New Collaboration with UCSF

                                                                                                                                                                                                                                                                                                        Sep 21, 2017: Alligator Bioscience to present ADC-1013 intratumoral clinical phase I study results at SITC in November 2017

                                                                                                                                                                                                                                                                                                          Sep 20, 2017: The Parker Institute for Cancer Immunotherapy and the Cancer Research Institute Announce First Patients Treated in Pancreatic Cancer Clinical Trial Combining Immunotherapy and Chemotherapy

                                                                                                                                                                                                                                                                                                            Jul 17, 2017: Apexigen Announces First Patient Dosed in Phase 1b/2 Clinical Trial of APX005M in Combination with Opdivo (nivolumab) in Advanced Solid Tumors

                                                                                                                                                                                                                                                                                                              May 10, 2017: Boehringer Ingelheim Phase II trial Now Enrolling Patients with the Kidney Disease Lupus Nephritis

                                                                                                                                                                                                                                                                                                                Appendix

                                                                                                                                                                                                                                                                                                                  Methodology

                                                                                                                                                                                                                                                                                                                    Coverage

                                                                                                                                                                                                                                                                                                                      Secondary Research

                                                                                                                                                                                                                                                                                                                        Primary Research

                                                                                                                                                                                                                                                                                                                          Expert Panel Validation

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                                                                                                                                                                                                                                                                                                                              Get latest Market Research Reports on Tumor Necrosis Factor Receptor Superfamily Member 5 . Industry analysis & Market Report on Tumor Necrosis Factor Receptor Superfamily Member 5 is a syndicated market report, published as Tumor Necrosis Factor Receptor Superfamily Member 5 (B Cell Surface Antigen CD40 or Bp50 or CDw40 or CD40L Receptor or TNFRSF5 or CD40) - Pipeline Review, H1 2019. It is complete Research Study and Industry Analysis of Tumor Necrosis Factor Receptor Superfamily Member 5 market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.

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