Report Detail

Pharma & Healthcare T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Pipeline Review, H1 2019

  • RnM3373215
  • |
  • 02 May, 2019
  • |
  • Global
  • |
  • 77 Pages
  • |
  • Global Markets Direct
  • |
  • Pharma & Healthcare

T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Pipeline Review, H1 2019

Summary

According to the recently published report 'T Cell Surface Glycoprotein CD3 Epsilon Chain - Pipeline Review, H1 2019'; T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) pipeline Target constitutes close to 14 molecules. Out of which approximately 11 molecules are developed by companies and remaining by the universities/institutes.

T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - T-Cell surface glycoprotein CD3 epsilon chain also known as CD3E is a polypeptide encoded by the CD3E gene. T-cell surface glycoprotein CD3 epsilon chain interacts with TOP2B, CD3EAPand NCK2. The CD3 complex mediates signal transduction, resulting in T-cell activation and proliferation.

The report 'T Cell Surface Glycoprotein CD3 Epsilon Chain - Pipeline Review, H1 2019' outlays comprehensive information on the T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

It also reviews key players involved in T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Phase III, Phase II, Phase I, Preclinical and Discovery stages are 2, 2, 3, 3 and 1 respectively. Similarly, the universities portfolio in Preclinical stages comprises 3 molecules, respectively.

Report covers products from therapy areas Oncology, Metabolic Disorders, Central Nervous System, Gastrointestinal, Genetic Disorders, Immunology and Infectious Disease which include indications Acute Lymphocytic Leukemia (ALL, Acute Lymphoblastic Leukemia), Diffuse Large B-Cell Lymphoma, Follicular Lymphoma, Multiple Sclerosis, Type 1 Diabetes (Juvenile Diabetes), Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Amyotrophic Lateral Sclerosis, B-Cell Leukemia, B-Cell Non-Hodgkin Lymphoma, Chronic Inflammation, Crohn's Disease (Regional Enteritis), Down Syndrome, Extranodal Marginal Zone B-Cell Lymphoma (Mucosa-Associated Lymphoid Tissue or MALT-Lymphoma), Hepatitis B, Hormone Refractory (Castration Resistant, Androgen-Independent) Prostate Cancer, Lymphoblastic Lymphoma, Multiple Myeloma (Kahler Disease), Nodal Marginal Zone B-Cell Lymphoma, Non Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), Primary Biliary Cirrhosis, Primary Mediastinal B-Cell Lymphoma, Prostate Cancer, Psoriasis, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Rheumatoid Arthritis, Solid Tumor, Splenic Marginal Zone B-Cell Lymphoma, Traumatic Brain Injury, Type 2 Diabetes and Waldenstrom Macroglobulinemia (Lymphoplasmacytic Lymphoma).

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E)
- The report reviews T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) targeted therapeutics and enlists all their major and minor projects
- The report assesses T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope


Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Overview

              T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Therapeutics Development

                Products under Development by Stage of Development

                  Products under Development by Therapy Area

                    Products under Development by Indication

                      Products under Development by Companies

                        Products under Development by Universities/Institutes

                          T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Therapeutics Assessment

                            Assessment by Mechanism of Action

                              Assessment by Route of Administration

                                Assessment by Molecule Type

                                  T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Companies Involved in Therapeutics Development

                                    Amgen Inc

                                      Avacta Life Sciences Ltd

                                        Celgene Corp

                                          F. Hoffmann-La Roche Ltd

                                            Numab Innovation AG

                                              Provention Bio Inc

                                                SYNIMMUNE GmbH

                                                  Tiziana Life Sciences Plc

                                                    T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Drug Profiles

                                                      AMG-330 - Drug Profile

                                                        Product Description

                                                          Mechanism Of Action

                                                            R&D Progress

                                                              AVA-002 - Drug Profile

                                                                Product Description

                                                                  Mechanism Of Action

                                                                    R&D Progress

                                                                      Bispecific Monoclonal Antibodies to Target CD3, CD16 and HBsAg for HBV Infection and Oncology - Drug Profile

                                                                        Product Description

                                                                          Mechanism Of Action

                                                                            R&D Progress

                                                                              Bispecific Monoclonal Antibody to Target CD3E and PSMA for Prostate Cancer - Drug Profile

                                                                                Product Description

                                                                                  Mechanism Of Action

                                                                                    R&D Progress

                                                                                      blinatumomab - Drug Profile

                                                                                        Product Description

                                                                                          Mechanism Of Action

                                                                                            R&D Progress

                                                                                              EM-801 - Drug Profile

                                                                                                Product Description

                                                                                                  Mechanism Of Action

                                                                                                    R&D Progress

                                                                                                      foralumab - Drug Profile

                                                                                                        Product Description

                                                                                                          Mechanism Of Action

                                                                                                            R&D Progress

                                                                                                              Fusion Protein to target CD3E and Cells Expressing NKG2D for Oncology - Drug Profile

                                                                                                                Product Description

                                                                                                                  Mechanism Of Action

                                                                                                                    R&D Progress

                                                                                                                      ND-007 - Drug Profile

                                                                                                                        Product Description

                                                                                                                          Mechanism Of Action

                                                                                                                            R&D Progress

                                                                                                                              otelixizumab - Drug Profile

                                                                                                                                Product Description

                                                                                                                                  Mechanism Of Action

                                                                                                                                    R&D Progress

                                                                                                                                      pasotuxizumab - Drug Profile

                                                                                                                                        Product Description

                                                                                                                                          Mechanism Of Action

                                                                                                                                            R&D Progress

                                                                                                                                              RO-7082859 - Drug Profile

                                                                                                                                                Product Description

                                                                                                                                                  Mechanism Of Action

                                                                                                                                                    R&D Progress

                                                                                                                                                      TACSYN - Drug Profile

                                                                                                                                                        Product Description

                                                                                                                                                          Mechanism Of Action

                                                                                                                                                            R&D Progress

                                                                                                                                                              teplizumab - Drug Profile

                                                                                                                                                                Product Description

                                                                                                                                                                  Mechanism Of Action

                                                                                                                                                                    R&D Progress

                                                                                                                                                                      T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Dormant Products

                                                                                                                                                                        T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Product Development Milestones

                                                                                                                                                                          Featured News & Press Releases

                                                                                                                                                                            Apr 09, 2019: Provention Bio Initiates Phase 3 PROTECT clinical trial with PRV-031 (Teplizumab) in patients with recent onset Type 1 Diabetes

                                                                                                                                                                              Mar 20, 2019: Tiziana submits IND application for oral formulation of Foralumab for treatment of NASH

                                                                                                                                                                                Mar 06, 2019: Blinatumomab for acute lymphoblastic leukaemia for people with minimal residual disease activity in remission

                                                                                                                                                                                  Jan 23, 2019: Amgen’s Blincyto gets expanded indication for B-cell ALL in Europe

                                                                                                                                                                                    Dec 03, 2018: Amgen announces first-in-human data evaluating investigational novel BiTE Immunotherapy AMG 330 At ASH 2018

                                                                                                                                                                                      Nov 28, 2018: Tiziana announces initiation of phase 1 clinical trial with nasal administration of Foralumab, a fully human anti-cluster definition 3 monoclonal antibody (anti-CD3 mAb), in healthy volunteers

                                                                                                                                                                                        Nov 27, 2018: BLINCYTO for drip infusion 35 µg launched in Japan for the treatment of relapsed or refractory B-cell acute lymphoblastic leukemia

                                                                                                                                                                                          Nov 16, 2018: Amgen receives CHMP positive opinion to expand use Of BLINCYTO (Blinatumomab) in patients with minimal residual disease-positive B-Cell precursor Acute Lymphoblastic Leukemia

                                                                                                                                                                                            Nov 01, 2018: Roche presents early data for novel T-cell engaging bispecific antibody CD20-TCB at the American Society of Hematology 2018 Annual Meeting

                                                                                                                                                                                              Nov 01, 2018: Amgen to present new data on Blinatumomab at ASH 2018

                                                                                                                                                                                                Nov 01, 2018: Amgen to present new data on its acute myeloid leukemia drug candidate AMG 330 at ASH 2018

                                                                                                                                                                                                  Sep 24, 2018: U.S. Food and Drug Administration approves application for Investigational New Drug; Phase I clinical study set to commence enrolment in late 2018

                                                                                                                                                                                                    Sep 24, 2018: BLINCYTO (blinatumomab) approved in japan for the treatment of Relapsed or Refractory B-cell Acute Lymphoblastic Leukemia

                                                                                                                                                                                                      Aug 29, 2018: European Commission approves BLINCYTO (blinatumomab) for use in pediatric patients with philadelphia chromosome-negative relapsed or refractory B-cell precursor acute lymphoblastic leukemia

                                                                                                                                                                                                        Aug 16, 2018: Tiziana Life Sciences: filing of investigational new drug application

                                                                                                                                                                                                          Appendix

                                                                                                                                                                                                            Methodology

                                                                                                                                                                                                              Coverage

                                                                                                                                                                                                                Secondary Research

                                                                                                                                                                                                                  Primary Research

                                                                                                                                                                                                                    Expert Panel Validation

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                                                                                                                                                                                                                        Get latest Market Research Reports on T Cell Surface Glycoprotein . Industry analysis & Market Report on T Cell Surface Glycoprotein is a syndicated market report, published as T Cell Surface Glycoprotein CD3 Epsilon Chain (T Cell Surface Antigen T3/Leu 4 Epsilon Chain or CD3E) - Pipeline Review, H1 2019. It is complete Research Study and Industry Analysis of T Cell Surface Glycoprotein market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.

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