Report Detail

Retinoic Acid Receptor Beta - Pipeline Review, H2 2019

Summary

According to the recently published report 'Retinoic Acid Receptor Beta - Pipeline Review, H2 2019'; Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) pipeline Target constitutes close to 16 molecules. Out of which approximately 15 molecules are developed by companies and remaining by the universities/institutes.

Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Retinoic acid receptor beta (RARB) is a nuclear receptor that is encoded by the RARB gene. RARB bind as heterodimers to the target response elements in response to their ligands (all-trans or 9-cis retinoic acid) and gene expression in various biological processes. In the absence or presence of hormone ligand, acts mainly as anregulate activator of gene expression due to weak binding to co-repressors. It is required for skeletal growth, matrix homeostasis and growth plate functions.

The report 'Retinoic Acid Receptor Beta - Pipeline Review, H2 2019' outlays comprehensive information on the Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

It also reviews key players involved in Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Preclinical and Discovery stages are 2, 6, 2, 4 and 1 respectively. Similarly, the universities portfolio in Phase I stages comprises 1 molecules, respectively. Report covers products from therapy areas Dermatology, Gastrointestinal, Respiratory, Central Nervous System, Hematological Disorders, Immunology, Metabolic Disorders, Oncology and Ophthalmology which include indications Acne Vulgaris, Bronchopulmonary Dysplasia, Acute Myelocytic Leukemia (AML, Acute Myeloblastic Leukemia), Acute Promyelocytic Leukemia, Breast Cancer, Germ Cell Tumors, Hyperlipidemia, Inflammatory Bowel Disease, Myelodysplastic Syndrome, Neuroblastoma, Neutropenia, Non Alcoholic Fatty Liver Disease (NAFLD), Non-Alcoholic Steatohepatitis (NASH), Psoriasis, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Retinopathy Of Prematurity, Sarcomas, Spinal Cord Injury, Traumatic Nerve Injury and Type 2 Diabetes.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB)
- The report reviews Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) targeted therapeutics and enlists all their major and minor projects
- The report assesses Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope


Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Overview

              Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Therapeutics Development

                Products under Development by Stage of Development

                  Products under Development by Therapy Area

                    Products under Development by Indication

                      Products under Development by Companies

                        Products under Development by Universities/Institutes

                          Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Therapeutics Assessment

                            Assessment by Mechanism of Action

                              Assessment by Route of Administration

                                Assessment by Molecule Type

                                  Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Companies Involved in Therapeutics Development

                                    3SBio Inc

                                      Advent Therapeutics Inc

                                        Bausch Health Companies Inc

                                          Lee's Pharmaceutical Holdings Ltd

                                            Orphanix GmbH

                                              Ortho Dermatologics Inc

                                                Phosphagenics Ltd

                                                  Promius Pharma LLC

                                                    Sol-Gel Technologies Ltd

                                                      Sunny BioDiscovery Inc

                                                        Sveikatal Inc

                                                          TherapyX Inc

                                                            Toko Pharmaceutical Industries Co Ltd

                                                              Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Drug Profiles

                                                                (adapalene + benzoyl peroxide + clindamycin phosphate) - Drug Profile

                                                                  Product Description

                                                                    Mechanism Of Action

                                                                      R&D Progress

                                                                        (adapalene + clindamycin hydrochloride) - Drug Profile

                                                                          Product Description

                                                                            Mechanism Of Action

                                                                              R&D Progress

                                                                                (benzoyl peroxide + tretinoin) - Drug Profile

                                                                                  Product Description

                                                                                    Mechanism Of Action

                                                                                      R&D Progress

                                                                                        (benzoyl peroxide + tretinoin) - Drug Profile

                                                                                          Product Description

                                                                                            Mechanism Of Action

                                                                                              R&D Progress

                                                                                                (clindamycin phosphate + tretinoin) - Drug Profile

                                                                                                  Product Description

                                                                                                    Mechanism Of Action

                                                                                                      R&D Progress

                                                                                                        (TPX-6001 + tretinoin) - Drug Profile

                                                                                                          Product Description

                                                                                                            Mechanism Of Action

                                                                                                              R&D Progress

                                                                                                                AC-261066 - Drug Profile

                                                                                                                  Product Description

                                                                                                                    Mechanism Of Action

                                                                                                                      R&D Progress

                                                                                                                        alitretinoin - Drug Profile

                                                                                                                          Product Description

                                                                                                                            Mechanism Of Action

                                                                                                                              R&D Progress

                                                                                                                                KCL-286 - Drug Profile

                                                                                                                                  Product Description

                                                                                                                                    Mechanism Of Action

                                                                                                                                      R&D Progress

                                                                                                                                        SBD-073 - Drug Profile

                                                                                                                                          Product Description

                                                                                                                                            Mechanism Of Action

                                                                                                                                              R&D Progress

                                                                                                                                                tamibarotene - Drug Profile

                                                                                                                                                  Product Description

                                                                                                                                                    Mechanism Of Action

                                                                                                                                                      R&D Progress

                                                                                                                                                        tazarotene - Drug Profile

                                                                                                                                                          Product Description

                                                                                                                                                            Mechanism Of Action

                                                                                                                                                              R&D Progress

                                                                                                                                                                tazarotene - Drug Profile

                                                                                                                                                                  Product Description

                                                                                                                                                                    Mechanism Of Action

                                                                                                                                                                      R&D Progress

                                                                                                                                                                        tretinoin - Drug Profile

                                                                                                                                                                          Product Description

                                                                                                                                                                            Mechanism Of Action

                                                                                                                                                                              R&D Progress

                                                                                                                                                                                tretinoin - Drug Profile

                                                                                                                                                                                  Product Description

                                                                                                                                                                                    Mechanism Of Action

                                                                                                                                                                                      R&D Progress

                                                                                                                                                                                        vitamin A palmitate - Drug Profile

                                                                                                                                                                                          Product Description

                                                                                                                                                                                            Mechanism Of Action

                                                                                                                                                                                              R&D Progress

                                                                                                                                                                                                vitamin A palmitate - Drug Profile

                                                                                                                                                                                                  Product Description

                                                                                                                                                                                                    Mechanism Of Action

                                                                                                                                                                                                      R&D Progress

                                                                                                                                                                                                        Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Dormant Products

                                                                                                                                                                                                          Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Discontinued Products

                                                                                                                                                                                                            Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Product Development Milestones

                                                                                                                                                                                                              Featured News & Press Releases

                                                                                                                                                                                                                Oct 24, 2019: Syros Announces new data from phase 2 trial of SY-1425 in combination with azacitidine demonstrating high response rates, rapid onset of action and favorable tolerability profile in RARA-Positive Newly Diagnosed Unfit AML Patients

                                                                                                                                                                                                                  Oct 15, 2019: Bausch Health's Ortho Dermatologics business to present data on tazarotene at The Fall Clinical Dermatology Conference

                                                                                                                                                                                                                    Oct 15, 2019: Bausch Health's Ortho Dermatologics business to present data on acne drug tretinoin at The Fall Clinical Dermatology Conference

                                                                                                                                                                                                                      Aug 07, 2019: Ortho Dermatologics announces U.S. FDA filing acceptance for IDP-123 treatment for Acne Vulgaris in lotion form

                                                                                                                                                                                                                        Aug 01, 2019: Syros highlights key accomplishments and provides milestone update on SY-1425

                                                                                                                                                                                                                          Jul 09, 2019: GSK's Alitoc becoming salvation treatment for chronic hand eczema patients

                                                                                                                                                                                                                            Apr 15, 2019: Sol-Gel Technologies announces 50% enrollment in pivotal phase III TWIN Program for the treatment of Acne Vulgaris

                                                                                                                                                                                                                              Jan 06, 2019: Syros provides update on its acute myeloid leukemia drug candidate SY-1425

                                                                                                                                                                                                                                Dec 17, 2018: Sol-Gel Technologies initiates pivotal phase III clinical program of TWIN for the treatment of acne vulgaris

                                                                                                                                                                                                                                  Dec 02, 2018: Syros announces promising clinical data from ongoing phase 2 trial of SY-1425 in genomically defined AML and MDS patients at ASH Annual Meeting

                                                                                                                                                                                                                                    Nov 01, 2018: Syros to present initial clinical data from combination cohorts in its ongoing phase 2 Trial of SY-1425 at ASH annual meeting

                                                                                                                                                                                                                                      Oct 30, 2018: Bausch Health launches ALTRENO (tretinoin) Lotion, 0.05% in the United States

                                                                                                                                                                                                                                        Oct 15, 2018: Bausch Health's ortho dermatologics business to present on ALTRENO During The Fall Clinical Dermatology Conference

                                                                                                                                                                                                                                          Oct 11, 2018: Bausch Health announces publication of pivotal phase 3 efficacy and safety data on ALTRENO (tretinoin) Lotion, 0.05%, in the journal of drugs in dermatology

                                                                                                                                                                                                                                            Sep 04, 2018: Sol-Gel Technologies provides program update for TWIN for the treatment of acne vulgaris

                                                                                                                                                                                                                                              Appendix

                                                                                                                                                                                                                                                Methodology

                                                                                                                                                                                                                                                  Coverage

                                                                                                                                                                                                                                                    Secondary Research

                                                                                                                                                                                                                                                      Primary Research

                                                                                                                                                                                                                                                        Expert Panel Validation

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                                                                                                                                                                                                                                                            Get latest Market Research Reports on Retinoic Acid Receptor Beta. Industry analysis & Market Report on Retinoic Acid Receptor Beta is a syndicated market report, published as Retinoic Acid Receptor Beta (RAR Beta or HBV Activated Protein or Nuclear Receptor Subfamily 1 Group B Member 2 or RAR Epsilon or NR1B2 or RARB) - Pipeline Review, H1 2019. It is complete Research Study and Industry Analysis of Retinoic Acid Receptor Beta market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.

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