Report Detail
Global Phase Change Refrigeration Cryotherapy Ablation Device Market 2026 by Manufacturers, Regions, Type and Application, Forecast to 2032
- RnM4730682 |
- 13 August, 2026 |
- Global |
- 73 Pages |
- GIR |
- Medical Devices & Consumables
According to our (Global Info Research) latest study, the global Phase Change Refrigeration Cryotherapy Ablation Device market size was valued at US$ 175 million in 2025 and is forecast to a readjusted size of US$ 1042 million by 2032 with a CAGR of 29.4% during review period.
In 2025, global sales of phase-change refrigeration cryoablation devices reached 330 units, with an average price of $516,000 per unit.
Cryoablation refers to a method of freezing diseased tissue through low-temperature technology to achieve in situ inactivation of solid tissue. The working principle is to use low temperature to quickly cool down the diseased tissue to destroy cells, causing cell necrosis or apoptosis, thereby achieving the purpose of treatment. Since cryoablation uses the physical method of energy exchange to achieve the purpose of treatment, its trauma and side effects to the human body are much lower than conventional radiotherapy and chemotherapy, so it is hailed as a "green therapy".
Traditional cryoablation equipment needs to be connected to high-pressure argon and helium cylinders when used, and the whole set of equipment becomes large and cumbersome. It is necessary to prepare a special warehouse to store a large number of gas cylinders. It is very inconvenient to use in hospitals where every inch of land is valuable, which affects its promotion and use. The new cryoablation adopts phase change heat transfer technology, selects liquid nitrogen and anhydrous ethanol vapor as phase change heat transfer media, can adopt a simple integrated design, and operate at low pressure. The working pressure of traditional cryoablation equipment is hundreds of atmospheres, and the working pressure of the new cryoablation is below 10 atmospheres, which is highly safe.
These devices utilize liquid nitrogen or specialized phase-change working fluids (such as anhydrous ethanol or Freon substitutes) as the cooling medium. The core material components include: the main unit—comprising the phase-change fluid storage and circulation system (liquid nitrogen Dewar/self-pressurizing tank, cryogenic pump, phase-change heat exchanger), the intelligent temperature control and monitoring system (temperature sensors, pressure sensors, PLC controllers), vacuum-insulated transfer lines, and a stainless steel or aluminum alloy chassis; and disposable consumables—comprising phase-change ablation needles (featuring stainless steel or Nitinol needle shafts with internal phase-change chambers and capillary structures), polyurethane or silicone catheters, polyoxymethylene (POM) connectors, and sterile packaging. Compared to Joule-Thomson gas-based systems, phase-change refrigeration eliminates the need for high-pressure argon/helium cylinders and associated high-pressure piping, significantly reducing raw material costs for the gas supply system; however, it imposes stricter requirements regarding the purity of the phase-change fluid, the sealing integrity of the cryogenic pump, and the heat transfer efficiency of the heat exchanger.
Regarding cost structure, the phase-change fluid circulation system (liquid nitrogen tank, cryogenic pump, heat exchanger) accounts for approximately 35–45% of the main unit's cost, the temperature control and monitoring system for about 20–25%, and the insulated piping and chassis for roughly 15–20%. Due to their internal phase-change chambers and capillary structures, the manufacturing complexity of the disposable ablation needles is comparable to that of gas-based needles; their retail price ranges from 8,000 to 15,000 RMB per unit, with raw material costs representing approximately 12–18% of the total. The core cost advantage of the phase-change cooling approach lies in operations: the unit price of liquid nitrogen is approximately 0.5–1.5 RMB/liter—far lower than the ongoing procurement costs for argon or helium—and it eliminates the need for specialized high-pressure gas cylinder storage facilities, thereby reducing hospital infrastructure investment by 30–50%. However, a disadvantage is the evaporative loss associated with liquid nitrogen storage (a daily evaporation rate of about 1–3%), which places high demands on the stability of the hospital's liquid nitrogen supply chain. Overall, while the initial purchase cost of the main unit for phase-change cooling equipment may be comparable to or slightly lower than that of gas-based systems, the simplification of the gas supply infrastructure and reduced reliance on consumables can lower the total lifecycle cost (over 5–8 years) by approximately 20–35%, making it highly cost-competitive for primary care hospitals and emerging markets.
This report is a detailed and comprehensive analysis for global Phase Change Refrigeration Cryotherapy Ablation Device market. Both quantitative and qualitative analyses are presented by manufacturers, by region & country, by Type and by Application. As the market is constantly changing, this report explores the competition, supply and demand trends, as well as key factors that contribute to its changing demands across many markets. Company profiles and product examples of selected competitors, along with market share estimates of some of the selected leaders for the year 2025, are provided.
Key Features:
Global Phase Change Refrigeration Cryotherapy Ablation Device market size and forecasts, in consumption value ($ Million), sales quantity (Units), and average selling prices (US$/Unit), 2021-2032
Global Phase Change Refrigeration Cryotherapy Ablation Device market size and forecasts by region and country, in consumption value ($ Million), sales quantity (Units), and average selling prices (US$/Unit), 2021-2032
Global Phase Change Refrigeration Cryotherapy Ablation Device market size and forecasts, by Type and by Application, in consumption value ($ Million), sales quantity (Units), and average selling prices (US$/Unit), 2021-2032
Global Phase Change Refrigeration Cryotherapy Ablation Device market shares of main players, shipments in revenue ($ Million), sales quantity (Units), and ASP (US$/Unit), 2021-2026
The Primary Objectives in This Report Are:
To determine the size of the total market opportunity of global and key countries
To assess the growth potential for Phase Change Refrigeration Cryotherapy Ablation Device
To forecast future growth in each product and end-use market
To assess competitive factors affecting the marketplace
This report profiles key players in the global Phase Change Refrigeration Cryotherapy Ablation Device market based on the following parameters - company overview, sales quantity, revenue, price, gross margin, product portfolio, geographical presence, and key developments. Key companies covered as a part of this study include Icecure Medical (IL), Hygea Beijing (CN), STERIS (US), etc.
This report also provides key insights about market drivers, restraints, opportunities, new product launches or approvals.
Market Segmentation
Phase Change Refrigeration Cryotherapy Ablation Device market is split by Type and by Application. For the period 2021-2032, the growth among segments provides accurate calculations and forecasts for consumption value by Type, and by Application in terms of volume and value. This analysis can help you expand your business by targeting qualified niche markets.
Market segment by Type
Liquid Nitrogen
Argon and Helium
Carbon Dioxide and Nitrous Oxide
Others
Market segment by Probe Diameter
1.3-1.5mm
1.7mm
2.4-3.5mm
Market segment by Image Guidance Method
CT-guided
Ultrasound-guided
MRI-guided
Market segment by Application
Tumor Treatment
Heart Treatment
Others
Major players covered
Icecure Medical (IL)
Hygea Beijing (CN)
STERIS (US)
Market segment by region, regional analysis covers
North America (United States, Canada, and Mexico)
Europe (Germany, France, United Kingdom, Russia, Italy, and Rest of Europe)
Asia-Pacific (China, Japan, Korea, India, Southeast Asia, and Australia)
South America (Brazil, Argentina, Colombia, and Rest of South America)
Middle East & Africa (Saudi Arabia, UAE, Egypt, South Africa, and Rest of Middle East & Africa)
The content of the study subjects, includes a total of 15 chapters:
Chapter 1, to describe Phase Change Refrigeration Cryotherapy Ablation Device product scope, market overview, market estimation caveats and base year.
Chapter 2, to profile the top manufacturers of Phase Change Refrigeration Cryotherapy Ablation Device, with price, sales quantity, revenue, and global market share of Phase Change Refrigeration Cryotherapy Ablation Device from 2021 to 2026.
Chapter 3, the Phase Change Refrigeration Cryotherapy Ablation Device competitive situation, sales quantity, revenue, and global market share of top manufacturers are analyzed emphatically by landscape contrast.
Chapter 4, the Phase Change Refrigeration Cryotherapy Ablation Device breakdown data are shown at the regional level, to show the sales quantity, consumption value, and growth by regions, from 2021 to 2032.
Chapter 5 and 6, to segment the sales by Type and by Application, with sales market share and growth rate by Type, by Application, from 2021 to 2032.
Chapter 7, 8, 9, 10 and 11, to break the sales data at the country level, with sales quantity, consumption value, and market share for key countries in the world, from 2021 to 2026.and Phase Change Refrigeration Cryotherapy Ablation Device market forecast, by regions, by Type, and by Application, with sales and revenue, from 2027 to 2032.
Chapter 12, market dynamics, drivers, restraints, trends, and Porters Five Forces analysis.
Chapter 13, the key raw materials and key suppliers, and industry chain of Phase Change Refrigeration Cryotherapy Ablation Device.
Chapter 14 and 15, to describe Phase Change Refrigeration Cryotherapy Ablation Device sales channel, distributors, customers, research findings and conclusion.
1 Market Overview
- 1.1 Product Overview and Scope
- 1.2 Market Estimation Caveats and Base Year
- 1.3 Market Analysis by Type
- 1.3.1 Overview: Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Type: 2021 Versus 2025 Versus 2032
- 1.3.2 Liquid Nitrogen
- 1.3.3 Argon and Helium
- 1.3.4 Carbon Dioxide and Nitrous Oxide
- 1.3.5 Others
- 1.4 Market Analysis by Probe Diameter
- 1.4.1 Overview: Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Probe Diameter: 2021 Versus 2025 Versus 2032
- 1.4.2 1.3-1.5mm
- 1.4.3 1.7mm
- 1.4.4 2.4-3.5mm
- 1.5 Market Analysis by Image Guidance Method
- 1.5.1 Overview: Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Image Guidance Method: 2021 Versus 2025 Versus 2032
- 1.5.2 CT-guided
- 1.5.3 Ultrasound-guided
- 1.5.4 MRI-guided
- 1.6 Market Analysis by Application
- 1.6.1 Overview: Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Application: 2021 Versus 2025 Versus 2032
- 1.6.2 Tumor Treatment
- 1.6.3 Heart Treatment
- 1.6.4 Others
- 1.7 Global Phase Change Refrigeration Cryotherapy Ablation Device Market Size & Forecast
- 1.7.1 Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value (2021 & 2025 & 2032)
- 1.7.2 Global Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity (2021-2032)
- 1.7.3 Global Phase Change Refrigeration Cryotherapy Ablation Device Average Price (2021-2032)
2 Manufacturers Profiles
- 2.1 Icecure Medical (IL)
- 2.1.1 Icecure Medical (IL) Details
- 2.1.2 Icecure Medical (IL) Major Business
- 2.1.3 Icecure Medical (IL) Phase Change Refrigeration Cryotherapy Ablation Device Product and Services
- 2.1.4 Icecure Medical (IL) Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity, Average Price, Revenue, Gross Margin and Market Share (2021-2026)
- 2.1.5 Icecure Medical (IL) Recent Developments/Updates
- 2.2 Hygea Beijing (CN)
- 2.2.1 Hygea Beijing (CN) Details
- 2.2.2 Hygea Beijing (CN) Major Business
- 2.2.3 Hygea Beijing (CN) Phase Change Refrigeration Cryotherapy Ablation Device Product and Services
- 2.2.4 Hygea Beijing (CN) Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity, Average Price, Revenue, Gross Margin and Market Share (2021-2026)
- 2.2.5 Hygea Beijing (CN) Recent Developments/Updates
- 2.3 STERIS (US)
- 2.3.1 STERIS (US) Details
- 2.3.2 STERIS (US) Major Business
- 2.3.3 STERIS (US) Phase Change Refrigeration Cryotherapy Ablation Device Product and Services
- 2.3.4 STERIS (US) Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity, Average Price, Revenue, Gross Margin and Market Share (2021-2026)
- 2.3.5 STERIS (US) Recent Developments/Updates
3 Competitive Environment: Phase Change Refrigeration Cryotherapy Ablation Device by Manufacturer
- 3.1 Global Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Manufacturer (2021-2026)
- 3.2 Global Phase Change Refrigeration Cryotherapy Ablation Device Revenue by Manufacturer (2021-2026)
- 3.3 Global Phase Change Refrigeration Cryotherapy Ablation Device Average Price by Manufacturer (2021-2026)
- 3.4 Market Share Analysis (2025)
- 3.4.1 Producer Shipments of Phase Change Refrigeration Cryotherapy Ablation Device by Manufacturer Revenue ($MM) and Market Share (%): 2025
- 3.4.2 Top 3 Phase Change Refrigeration Cryotherapy Ablation Device Manufacturer Market Share in 2025
- 3.4.3 Top 6 Phase Change Refrigeration Cryotherapy Ablation Device Manufacturer Market Share in 2025
- 3.5 Phase Change Refrigeration Cryotherapy Ablation Device Market: Overall Company Footprint Analysis
- 3.5.1 Phase Change Refrigeration Cryotherapy Ablation Device Market: Region Footprint
- 3.5.2 Phase Change Refrigeration Cryotherapy Ablation Device Market: Company Product Type Footprint
- 3.5.3 Phase Change Refrigeration Cryotherapy Ablation Device Market: Company Product Application Footprint
- 3.6 New Market Entrants and Barriers to Market Entry
- 3.7 Mergers, Acquisition, Agreements, and Collaborations
4 Consumption Analysis by Region
- 4.1 Global Phase Change Refrigeration Cryotherapy Ablation Device Market Size by Region
- 4.1.1 Global Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Region (2021-2032)
- 4.1.2 Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Region (2021-2032)
- 4.1.3 Global Phase Change Refrigeration Cryotherapy Ablation Device Average Price by Region (2021-2032)
- 4.2 North America Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value (2021-2032)
- 4.3 Europe Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value (2021-2032)
- 4.4 Asia-Pacific Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value (2021-2032)
- 4.5 South America Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value (2021-2032)
- 4.6 Middle East & Africa Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value (2021-2032)
5 Market Segment by Type
- 5.1 Global Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Type (2021-2032)
- 5.2 Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Type (2021-2032)
- 5.3 Global Phase Change Refrigeration Cryotherapy Ablation Device Average Price by Type (2021-2032)
6 Market Segment by Application
- 6.1 Global Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Application (2021-2032)
- 6.2 Global Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Application (2021-2032)
- 6.3 Global Phase Change Refrigeration Cryotherapy Ablation Device Average Price by Application (2021-2032)
7 North America
- 7.1 North America Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Type (2021-2032)
- 7.2 North America Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Application (2021-2032)
- 7.3 North America Phase Change Refrigeration Cryotherapy Ablation Device Market Size by Country
- 7.3.1 North America Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Country (2021-2032)
- 7.3.2 North America Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Country (2021-2032)
- 7.3.3 United States Market Size and Forecast (2021-2032)
- 7.3.4 Canada Market Size and Forecast (2021-2032)
- 7.3.5 Mexico Market Size and Forecast (2021-2032)
8 Europe
- 8.1 Europe Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Type (2021-2032)
- 8.2 Europe Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Application (2021-2032)
- 8.3 Europe Phase Change Refrigeration Cryotherapy Ablation Device Market Size by Country
- 8.3.1 Europe Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Country (2021-2032)
- 8.3.2 Europe Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Country (2021-2032)
- 8.3.3 Germany Market Size and Forecast (2021-2032)
- 8.3.4 France Market Size and Forecast (2021-2032)
- 8.3.5 United Kingdom Market Size and Forecast (2021-2032)
- 8.3.6 Russia Market Size and Forecast (2021-2032)
- 8.3.7 Italy Market Size and Forecast (2021-2032)
9 Asia-Pacific
- 9.1 Asia-Pacific Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Type (2021-2032)
- 9.2 Asia-Pacific Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Application (2021-2032)
- 9.3 Asia-Pacific Phase Change Refrigeration Cryotherapy Ablation Device Market Size by Region
- 9.3.1 Asia-Pacific Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Region (2021-2032)
- 9.3.2 Asia-Pacific Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Region (2021-2032)
- 9.3.3 China Market Size and Forecast (2021-2032)
- 9.3.4 Japan Market Size and Forecast (2021-2032)
- 9.3.5 South Korea Market Size and Forecast (2021-2032)
- 9.3.6 India Market Size and Forecast (2021-2032)
- 9.3.7 Southeast Asia Market Size and Forecast (2021-2032)
- 9.3.8 Australia Market Size and Forecast (2021-2032)
10 South America
- 10.1 South America Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Type (2021-2032)
- 10.2 South America Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Application (2021-2032)
- 10.3 South America Phase Change Refrigeration Cryotherapy Ablation Device Market Size by Country
- 10.3.1 South America Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Country (2021-2032)
- 10.3.2 South America Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Country (2021-2032)
- 10.3.3 Brazil Market Size and Forecast (2021-2032)
- 10.3.4 Argentina Market Size and Forecast (2021-2032)
11 Middle East & Africa
- 11.1 Middle East & Africa Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Type (2021-2032)
- 11.2 Middle East & Africa Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Application (2021-2032)
- 11.3 Middle East & Africa Phase Change Refrigeration Cryotherapy Ablation Device Market Size by Country
- 11.3.1 Middle East & Africa Phase Change Refrigeration Cryotherapy Ablation Device Sales Quantity by Country (2021-2032)
- 11.3.2 Middle East & Africa Phase Change Refrigeration Cryotherapy Ablation Device Consumption Value by Country (2021-2032)
- 11.3.3 Turkey Market Size and Forecast (2021-2032)
- 11.3.4 Egypt Market Size and Forecast (2021-2032)
- 11.3.5 Saudi Arabia Market Size and Forecast (2021-2032)
- 11.3.6 South Africa Market Size and Forecast (2021-2032)
12 Market Dynamics
- 12.1 Phase Change Refrigeration Cryotherapy Ablation Device Market Drivers
- 12.2 Phase Change Refrigeration Cryotherapy Ablation Device Market Restraints
- 12.3 Phase Change Refrigeration Cryotherapy Ablation Device Trends Analysis
- 12.4 Porters Five Forces Analysis
- 12.4.1 Threat of New Entrants
- 12.4.2 Bargaining Power of Suppliers
- 12.4.3 Bargaining Power of Buyers
- 12.4.4 Threat of Substitutes
- 12.4.5 Competitive Rivalry
13 Raw Material and Industry Chain
- 13.1 Raw Material of Phase Change Refrigeration Cryotherapy Ablation Device and Key Manufacturers
- 13.2 Manufacturing Costs Percentage of Phase Change Refrigeration Cryotherapy Ablation Device
- 13.3 Phase Change Refrigeration Cryotherapy Ablation Device Production Process
- 13.4 Industry Value Chain Analysis
14 Shipments by Distribution Channel
- 14.1 Sales Channel
- 14.1.1 Direct to End-User
- 14.1.2 Distributors
- 14.2 Phase Change Refrigeration Cryotherapy Ablation Device Typical Distributors
- 14.3 Phase Change Refrigeration Cryotherapy Ablation Device Typical Customers
15 Research Findings and Conclusion
16 Appendix
- 16.1 Methodology
- 16.2 Research Process and Data Source
Summary:
Get latest Market Research Reports on Phase Change Refrigeration Cryotherapy Ablation Device. Industry analysis & Market Report on Phase Change Refrigeration Cryotherapy Ablation Device is a syndicated market report, published as Global Phase Change Refrigeration Cryotherapy Ablation Device Market 2026 by Manufacturers, Regions, Type and Application, Forecast to 2032. It is complete Research Study and Industry Analysis of Phase Change Refrigeration Cryotherapy Ablation Device market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.
REPORT YOU MIGHT BE INTERESTED
Related Reports
Reason to Buy
Reports and Markets
Contact Us
+1-352-353-0818 (US)Newsletter
KEEP UP TO DATE ON ALL THE LATEST REPORTS
