Report Detail

Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Pipeline Review, H1 2019

Summary

Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Peroxisome proliferator-activated receptor delta is a nuclear receptor that in humans is encoded by the PPARD gene. PPAR-delta is a nuclear hormone receptor that governs a variety of biological processes and involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. The expression of this gene is found to be elevated in colorectal cancer cells. The elevated expression can be repressed by adenomatosis polyposis coli (APC), a tumor suppressor protein involved in the APC/beta-catenin signaling pathway.

Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) pipeline Target constitutes close to 16 molecules. Out of which approximately 13 molecules are developed by companies and remaining by the universities/institutes. The molecules developed by companies in Phase III, Phase II, Phase I and Preclinical stages are 4, 4, 2 and 3 respectively.

Similarly, the universities portfolio in Preclinical and Discovery stages comprises 2 and 1 molecules, respectively. Report covers products from therapy areas Metabolic Disorders, Gastrointestinal, Central Nervous System, Oncology, Genetic Disorders, Genito Urinary System And Sex Hormones, Musculoskeletal Disorders, Ophthalmology, Immunology and Respiratory which include indications Non-Alcoholic Steatohepatitis (NASH), Acute Renal Failure (ARF) (Acute Kidney Injury), Duchenne Muscular Dystrophy, Dyslipidemia, Mitochondrial Diseases, Non Alcoholic Fatty Liver Disease (NAFLD), Primary Biliary Cirrhosis, Type 2 Diabetes, Alzheimer's Disease, Bone Disorders, Bone Fracture, Colitis, Familial Chylomicronemia (Type I Hyperlipoproteinemia), Hepatocellular Carcinoma, Huntington Disease, Idiopathic Pulmonary Fibrosis, Inflammation, Keratoconjunctivitis Sicca (Dry Eye), Leber’s Hereditary Optic Neuropathy (Leber Optic Atrophy), Liver Diseases, Liver Fibrosis, MELAS Syndrome (Mitochondrial Encephalomyopathy, Lactic Acidosis and Stroke-Like Episodes), Metabolic Syndrome, Obesity, Osteoarthritis, Osteoporosis and Parkinson's Disease.

The latest report Peroxisome Proliferator Activated Receptor Delta - Pipeline Review, H1 2019, outlays comprehensive information on the Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type. It also reviews key players involved in Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) targeted therapeutics development with respective active and dormant or discontinued projects.

The report is built using data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The report provides a snapshot of the global therapeutic landscape for Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD)
- The report reviews Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
- The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
- The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
- The report reviews key players involved in Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) targeted therapeutics and enlists all their major and minor projects
- The report assesses Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
- The report summarizes all the dormant and discontinued pipeline projects
- The report reviews latest news and deals related to Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) targeted therapeutics

Reasons to buy

- Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
- Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
- Identify and understand the targeted therapy areas and indications for Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD)
- Identify the use of drugs for target identification and drug repurposing
- Identify potential new clients or partners in the target demographic
- Develop strategic initiatives by understanding the focus areas of leading companies
- Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
- Devise corrective measures for pipeline projects by understanding Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) development landscape
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope


Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Overview

              Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Therapeutics Development

                Products under Development by Stage of Development

                  Products under Development by Therapy Area

                    Products under Development by Indication

                      Products under Development by Companies

                        Products under Development by Universities/Institutes

                          Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Therapeutics Assessment

                            Assessment by Mechanism of Action

                              Assessment by Route of Administration

                                Assessment by Molecule Type

                                  Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Companies Involved in Therapeutics Development

                                    Chipscreen Biosciences Ltd

                                      CymaBay Therapeutics Inc

                                        Genfit SA

                                          Inception Sciences Inc

                                            Inventiva

                                              Mitobridge Inc

                                                Nippon Chemiphar Co Ltd

                                                  Senju Pharmaceutical Co Ltd

                                                    T3D Therapeutics Inc

                                                      Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Drug Profiles

                                                        CS-038 - Drug Profile

                                                          Product Description

                                                            Mechanism Of Action

                                                              R&D Progress

                                                                Drugs to Modulate PPAR-Delta for Metabolic and Musculoskeletal Disorders - Drug Profile

                                                                  Product Description

                                                                    Mechanism Of Action

                                                                      R&D Progress

                                                                        elafibranor - Drug Profile

                                                                          Product Description

                                                                            Mechanism Of Action

                                                                              R&D Progress

                                                                                fonadelpar - Drug Profile

                                                                                  Product Description

                                                                                    Mechanism Of Action

                                                                                      R&D Progress

                                                                                        HPP-593 - Drug Profile

                                                                                          Product Description

                                                                                            Mechanism Of Action

                                                                                              R&D Progress

                                                                                                lanifibranor - Drug Profile

                                                                                                  Product Description

                                                                                                    Mechanism Of Action

                                                                                                      R&D Progress

                                                                                                        MA-0204 - Drug Profile

                                                                                                          Product Description

                                                                                                            Mechanism Of Action

                                                                                                              R&D Progress

                                                                                                                MA-0211 - Drug Profile

                                                                                                                  Product Description

                                                                                                                    Mechanism Of Action

                                                                                                                      R&D Progress

                                                                                                                        MA-0217 - Drug Profile

                                                                                                                          Product Description

                                                                                                                            Mechanism Of Action

                                                                                                                              R&D Progress

                                                                                                                                NC-2400 - Drug Profile

                                                                                                                                  Product Description

                                                                                                                                    Mechanism Of Action

                                                                                                                                      R&D Progress

                                                                                                                                        seladelpar lysine - Drug Profile

                                                                                                                                          Product Description

                                                                                                                                            Mechanism Of Action

                                                                                                                                              R&D Progress

                                                                                                                                                Small Molecule to Agonize PPAR Delta for Mitochondrial Diseases - Drug Profile

                                                                                                                                                  Product Description

                                                                                                                                                    Mechanism Of Action

                                                                                                                                                      R&D Progress

                                                                                                                                                        Small Molecule to Antagonize PPARA and PPARD for Oncology - Drug Profile

                                                                                                                                                          Product Description

                                                                                                                                                            Mechanism Of Action

                                                                                                                                                              R&D Progress

                                                                                                                                                                Small Molecules to Agonize PPAR-delta for Non-Alcoholic Steatoheptatis and Obesity - Drug Profile

                                                                                                                                                                  Product Description

                                                                                                                                                                    Mechanism Of Action

                                                                                                                                                                      R&D Progress

                                                                                                                                                                        Small Molecules to Inhibit PPAR Beta and PPAR Delta for Metabolic Disorders, Inflammatory Diseases and Oncology - Drug Profile

                                                                                                                                                                          Product Description

                                                                                                                                                                            Mechanism Of Action

                                                                                                                                                                              R&D Progress

                                                                                                                                                                                T-3D959 - Drug Profile

                                                                                                                                                                                  Product Description

                                                                                                                                                                                    Mechanism Of Action

                                                                                                                                                                                      R&D Progress

                                                                                                                                                                                        Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Dormant Products

                                                                                                                                                                                          Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Discontinued Products

                                                                                                                                                                                            Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Product Development Milestones

                                                                                                                                                                                              Featured News & Press Releases

                                                                                                                                                                                                Mar 12, 2019: Genfit to study elafibranor in Phase II trial for paediatric NASH

                                                                                                                                                                                                  Feb 21, 2019: Inventiva announces further progress achieved in the clinical development of lanifibranor for the treatment of NASH

                                                                                                                                                                                                    Feb 19, 2019: CymaBay Therapeutics announces early enrollment of a phase 2b study of seladelpar in patients with nonalcoholic steatohepatitis

                                                                                                                                                                                                      Feb 19, 2019: Inventiva’s lanifibranor fails to meet endpoint in FASST trial

                                                                                                                                                                                                        Feb 15, 2019: CymaBay Therapeutics announces seladelpar granted breakthrough therapy designation by the FDA for the treatment of primary biliary cholangitis

                                                                                                                                                                                                          Feb 04, 2019: INVENTIVA : New results on lanifibranor to be presented at the International Liver Congress 2019

                                                                                                                                                                                                            Dec 17, 2018: GENFIT: Positive 30-month DSMB recommendation for continuation of phase 3 RESOLVE-IT study of Elafibranor in NASH

                                                                                                                                                                                                              Dec 06, 2018: GENFIT: Positive phase 2 results from study of Elafibranor in primary biliary cholangitis

                                                                                                                                                                                                                Nov 13, 2018: Cymabay Therapeutics presents positive results from its ongoing phase 2 study of Seladelpar in patients with PBC at The Liver Meeting 2018

                                                                                                                                                                                                                  Oct 30, 2018: Cymabay announces the initiation of the Seladelpar global phase 3 registration study (enhance) for the treatment of primary biliary cholangitis and additional corporate updates

                                                                                                                                                                                                                    Oct 15, 2018: Inventiva announces last visit by last patient in its phase IIb SSC trial and second positive DSMB review in its phase IIbnash trial with Lanifibranor

                                                                                                                                                                                                                      Oct 10, 2018: Inventiva Announces Two Poster Presentations at the American College of Rheumatology Conference

                                                                                                                                                                                                                        Oct 03, 2018: Cymabay Therapeutics announces additional positive results from its ongoing phase 2 study of Seladelpar in patients with PBC will be presented during the late-breaking session at the liver meeting

                                                                                                                                                                                                                          Oct 02, 2018: GENFIT: New data to be presented at 2018 AASLD meeting, ahead of key results expected in 2018 and 2019

                                                                                                                                                                                                                            Aug 31, 2018: GENFIT announces its upcoming participation in a number of investor and NASH-specific events over the next two months

                                                                                                                                                                                                                              Appendix

                                                                                                                                                                                                                                Methodology

                                                                                                                                                                                                                                  Coverage

                                                                                                                                                                                                                                    Secondary Research

                                                                                                                                                                                                                                      Primary Research

                                                                                                                                                                                                                                        Expert Panel Validation

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                                                                                                                                                                                                                                            Get latest Market Research Reports on Peroxisome Proliferator Activated Receptor Delta. Industry analysis & Market Report on Peroxisome Proliferator Activated Receptor Delta is a syndicated market report, published as Peroxisome Proliferator Activated Receptor Delta (NUCI or Nuclear Hormone Receptor 1 or Nuclear Receptor Subfamily 1 Group C Member 2 or Peroxisome Proliferator Activated Receptor Beta or NR1C2 or PPARD) - Pipeline Review, H1 2019. It is complete Research Study and Industry Analysis of Peroxisome Proliferator Activated Receptor Delta market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.

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