Report Detail

Pharma & Healthcare Opioid-Induced Constipation (OIC) - Pipeline Review, H1 2019

  • RnM2890049
  • |
  • 06 February, 2019
  • |
  • Global
  • |
  • 51 Pages
  • |
  • Global Markets Direct
  • |
  • Pharma & Healthcare

Opioid-Induced Constipation (OIC) - Pipeline Review, H1 2019

Summary

Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Opioid-Induced Constipation (OIC) - Pipeline Review, H1 2019, provides an overview of the Opioid-Induced Constipation (OIC) (Toxicology) pipeline landscape.

Opioids are effective pain relievers, but often have the side effect of constipation. These medicines affect the gastrointestinal tract in a variety of ways. Opioids increase the amount of time it takes stool to move through the gastric system. They increase non-propulsive contractions in the middle of the small intestine (jejunum) and decrease longitudinal propulsive peristalsis - motions critical to moving food through the intestines. This results in food that fails to travel through the digestive tract. Opioids are also able to partially paralyze the stomach (gastroparesis) so that food remains in the digestive organ for a longer period of time. Additionally opioids reduce digestive secretions and decrease the urge to defecate. Symptoms of OIC include feeling and being sick, tiredness and lethargy, appetite loss, feeling depressed.

Report Highlights

Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Opioid-Induced Constipation (OIC) - Pipeline Review, H1 2019, provides comprehensive information on the therapeutics under development for Opioid-Induced Constipation (OIC) (Toxicology), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

The Opioid-Induced Constipation (OIC) (Toxicology) pipeline guide also reviews of key players involved in therapeutic development for Opioid-Induced Constipation (OIC) and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Pre-Registration, Phase III and Phase II stages are 1, 2 and 1 respectively. Similarly, the Universities portfolio in Preclinical stages comprises 1 molecules, respectively.

Opioid-Induced Constipation (OIC) (Toxicology) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

Scope

- The pipeline guide provides a snapshot of the global therapeutic landscape of Opioid-Induced Constipation (OIC) (Toxicology).
- The pipeline guide reviews pipeline therapeutics for Opioid-Induced Constipation (OIC) (Toxicology) by companies and universities/research institutes based on information derived from company and industry-specific sources.
- The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
- The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
- The pipeline guide reviews key companies involved in Opioid-Induced Constipation (OIC) (Toxicology) therapeutics and enlists all their major and minor projects.
- The pipeline guide evaluates Opioid-Induced Constipation (OIC) (Toxicology) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
- The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
- The pipeline guide reviews latest news related to pipeline therapeutics for Opioid-Induced Constipation (OIC) (Toxicology)

Reasons to buy

- Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
- Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
- Find and recognize significant and varied types of therapeutics under development for Opioid-Induced Constipation (OIC) (Toxicology).
- Classify potential new clients or partners in the target demographic.
- Develop tactical initiatives by understanding the focus areas of leading companies.
- Plan mergers and acquisitions meritoriously by identifying key players and it’s most promising pipeline therapeutics.
- Formulate corrective measures for pipeline projects by understanding Opioid-Induced Constipation (OIC) (Toxicology) pipeline depth and focus of Indication therapeutics.
- Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
- Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.


Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Opioid-Induced Constipation (OIC) - Overview

              Opioid-Induced Constipation (OIC) - Therapeutics Development

                Pipeline Overview

                  Pipeline by Companies

                    Pipeline by Universities/Institutes

                      Products under Development by Companies

                        Products under Development by Universities/Institutes

                          Opioid-Induced Constipation (OIC) - Therapeutics Assessment

                            Assessment by Target

                              Assessment by Mechanism of Action

                                Assessment by Route of Administration

                                  Assessment by Molecule Type

                                    Opioid-Induced Constipation (OIC) - Companies Involved in Therapeutics Development

                                      MallInckrodt Plc

                                        Shionogi & Co Ltd

                                          Synergy Pharmaceuticals Inc

                                            Opioid-Induced Constipation (OIC) - Drug Profiles

                                              dolcanatide - Drug Profile

                                                Product Description

                                                  Mechanism Of Action

                                                    R&D Progress

                                                      lubiprostone - Drug Profile

                                                        Product Description

                                                          Mechanism Of Action

                                                            R&D Progress

                                                              naldemedine tosylate - Drug Profile

                                                                Product Description

                                                                  Mechanism Of Action

                                                                    R&D Progress

                                                                      naloxone hydrochloride PR - Drug Profile

                                                                        Product Description

                                                                          Mechanism Of Action

                                                                            R&D Progress

                                                                              Small Molecule to Antagonize Mu Opioid Receptor for Drug Abuse, Alcohol Addiction and OIC - Drug Profile

                                                                                Product Description

                                                                                  Mechanism Of Action

                                                                                    R&D Progress

                                                                                      Opioid-Induced Constipation (OIC) - Dormant Projects

                                                                                        Opioid-Induced Constipation (OIC) - Discontinued Products

                                                                                          Opioid-Induced Constipation (OIC) - Product Development Milestones

                                                                                            Featured News & Press Releases

                                                                                              Dec 18, 2018: Shionogi receives positive opinion for Rizmoic in latest announcement from the Committee for Medicinal Products for Human Use (CHMP)

                                                                                                Dec 13, 2018: Rizmoic (naldemedine) received a positive opinion for the treatment of opioid-induced constipation

                                                                                                  Sep 04, 2018: Shionogi announces upcoming presentations from Symproic (naldemedine) studies at PAINWeek 2018 Annual Conference

                                                                                                    Jul 09, 2018: Shionogi Regains Full Rights to Symproic (naldemedine) in the US

                                                                                                      Mar 06, 2018: Fifty-Two Week Safety Study on Symproic (naldemedine) for Opioid-induced Constipation (OIC) in Adults with Chronic Non-cancer Pain Published in PAIN

                                                                                                        Oct 12, 2017: Shionogi and Purdue Pharma Announce U.S. Availability of Symproic (naldemedine) for the Treatment of Opioid-Induced Constipation in Adults with Chronic Non-Cancer Pain

                                                                                                          Sep 06, 2017: Shionogi and Purdue Pharma to Present Data from Naldemedine Studies at PAINWeek 2017 Annual Conference

                                                                                                            Jun 07, 2017: Opioid-Induced Constipation therapeutic agent ‘Symproic (naldemedine) Tablets 0.2mg’ launched in Japan

                                                                                                              Mar 30, 2017: Symproic (naldemedine) Approved for the Treatment of Opioid-Induced Constipation in Japan

                                                                                                                Mar 24, 2017: EMA Accepts MAA Submission of Shionogi’s Naldemedine for the Treatment of Opioid-Induced Constipation

                                                                                                                  Mar 23, 2017: FDA Approves Symproic (naldemedine) Once-Daily Tablets C-II for the Treatment of Opioid-Induced Constipation in Adults with Chronic Non-Cancer Pain

                                                                                                                    Dec 19, 2016: Shionogi and Purdue Pharma Establish Alliance for Joint U.S. Commercialization of Naldemedine

                                                                                                                      Sep 07, 2016: Naldemedine Phase III Study Demonstrates Long-Term Safety And Efficacy For The Treatment Of Opioid-Induced Constipation

                                                                                                                        Jun 06, 2016: Shionogi Announces Acceptance Of New Drug Application In The U.S. For Naldemedine For The Treatment Of Opioid-Induced Constipation

                                                                                                                          May 23, 2016: Two Naldemedine Phase III Studies Show Consistent Improvement Of Opioid-Induced Constipation

                                                                                                                            Appendix

                                                                                                                              Methodology

                                                                                                                                Coverage

                                                                                                                                  Secondary Research

                                                                                                                                    Primary Research

                                                                                                                                      Expert Panel Validation

                                                                                                                                        Contact Us

                                                                                                                                          Disclaimer

                                                                                                                                          Summary:
                                                                                                                                          Get latest Market Research Reports on Opioid-Induced Constipation (OIC). Industry analysis & Market Report on Opioid-Induced Constipation (OIC) is a syndicated market report, published as Opioid-Induced Constipation (OIC) - Pipeline Review, H1 2019. It is complete Research Study and Industry Analysis of Opioid-Induced Constipation (OIC) market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.

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