Chromatography

1 EXECUTIVE SUMMARY 33

2 INTRODUCTION 38

• 2.1 KEY TAKE AWAYS 38
• 2.2 REPORT DESCRIPTION 39
• 2.3 MARKETS COVERED 42
• 2.4 STAKEHOLDERS 44
• 2.5 RESEARCH METHODOLOGY 44
  • 2.5.1 MARKET SIZE ESTIMATION 46
  • 2.5.2 MARKET BREAKDOWN AND DATA TRIANGULATION 48
  • 2.5.3 SECONDARY SOURCES 49
  • 2.5.4 PRIMARY SOURCES 49
  • 2.5.5 KEY DATA POINTS FROM SECONDARY SOURCES 50
  • 2.5.6 KEY DATA POINTS FROM PRIMARY SOURCES 51
  • 2.5.7 ASSUMPTIONS 51

3 MARKET ANALYSIS 53

• 3.1 INTRODUCTION 53
• 3.2 MARKET SEGMENTATION 54
• 3.3 FACTORS INFLUENCING MARKET 56
  • 3.3.1 DRIVERS AND OPPORTUNITIES 57
    • 3.3.1.1 Rapid rise in biologics 57
    • 3.3.1.2 Growing importance of chromatography tests in drug approvals 57
    • 3.3.1.3 New international cgmp and cgdp certification for pharmaceutical excipients 58
    • 3.3.1.4 Technological advancements in chromatography instruments & reagents 59
    • 3.3.1.5 Increasing life sciences r&d spending 60
    • 3.3.1.6 Growing food safety concerns 61
    • 3.3.1.7 Increased use of chromatography in diverse applications 62
    • 3.3.1.8 Expanding emerging markets 63
  • 3.3.2 RESTRAINTS AND THREATS 63
    • 3.3.2.1 High unit and maintenance cost of advanced equipments. 63
    • 3.3.2.2 Mature product segment and pricing pressure 64
    • 3.3.2.3 Stringent regulations 65
• 3.4 PORTER’S FIVE FORCE ANALYSIS 66
  • 3.4.1 THREAT OF NEW ENTRANTS 67
  • 3.4.2 THREAT OF SUBSTITUTES 67
  • 3.4.3 RIVALRY AMONG EXISTING COMPETITORS 68
  • 3.4.4 BARGAINING POWER OF SUPPLIERS 68
  • 3.4.5 BARGAINING POWER OF BUYERS 68
• 3.5 REGULATORY AFFAIRS 69
  • 3.5.1 NORTH AMERICA 70
  • 3.5.2 EUROPE 72
  • 3.5.3 CHINA 73
  • 3.5.4 JAPAN 74
  • 3.5.5 INDIA 74
• 3.6 MARKET SHARE ANALYSIS 76
  • 3.6.1 MARKET SHARE ANALYSIS OF CHROMATOGRAPHY GLOBAL MARKET 76
  • 3.6.2 MARKET SHARE ANALYSIS OF HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) GLOBAL MARKET 78
  • 3.6.3 MARKET SHARE ANALYSIS OF LC-MS GLOBAL MARKET 80
  • 3.6.4 MARKET SHARE ANALYSIS OF GAS CHROMATOGRAPHY (GC) GLOBAL MARKET 82
  • 3.6.5 MARKET SHARE ANALYSIS OF GAS CHROMATOGRAPHY MASS SPECTROMETRY (GC-MS) GLOBAL MARKET 84
• 3.7 NEW PRODUCT LAUNCHES IN CHROMATOGRAPHY MARKET 85
• 3.8 TECHNOLOGICAL ADVANCEMENTS 90
  • 3.8.1 ADVANCEMENTS IN INSTRUMENTS 90
  • 3.8.2 ADVANCEMENTS IN CONSUMABLES 91
• 3.9 SUPPLY CHAIN ANALYSIS 92
• 3.10 REFURBISHED DEVICES 95

4 CHROMATOGRAPHY GLOBAL MARKET, BY PROCESS TYPE 97

• 4.1 INTRODUCTION 97
• 4.2 PREPARATIVE CHROMATOGRAPHY 98
• 4.3 PROCESS (ANALYTICAL) CHROMATOGRAPHY 102

5 CHROMATOGRAPHY GLOBAL MARKET, BY TECHNOLOGY 104

• 5.1 INTRODUCTION 104
• 5.2 LIQUID CHROMATOGRAPHY 106
  • 5.2.1 HIGH PERFORMANCE LIQUID CHROMATOGRAPHY (HPLC) 112
    • 5.2.1.1 Ultra-high pressure liquid chromatography (UHPLC) 113
    • 5.2.1.2 Reverse-phase chromatography 114
    • 5.2.1.3 Normal-phase chromatography 114
    • 5.2.1.4 Affinity chromatography 115
    • 5.2.1.5 Chiral chromatography 115
    • 5.2.1.6 Adsorption chromatography 115
    • 5.2.1.7 Multimodal chromatography 116
    • 5.2.1.8 Ion chromatography (Ion-exchange chromatography) 116
    • 5.2.1.9 Hydrophilic and hydrophobic interaction chromatography 116
  • 5.2.2 LIQUID CHROMATOGRAPHY-MASS SPECTROMETRY (LC-MS) 118
  • 5.2.3 OTHERS 121
• 5.3 THIN LAYER CHROMATOGRAPHY (TLC) 125
• 5.4 GAS CHROMATOGRAPHY (GC) 128
• 5.5 SUPERCRITICAL FLUID CHROMATOGRAPHY (SFC) 131

6 CHROMATOGRAPHY GLOBAL MARKET, BY PRODUCTS 135

• 6.1 INTRODUCTION 135
• 6.2 INSTRUMENTS 136
  • 6.2.1 SYSTEMS 141
  • 6.2.2 DETECTORS 142
    • 6.2.2.1 Liquid chromatography detectors 146
    • 6.2.2.1.1 UV visible detectors 149
    • 6.2.2.1.2 Refractive index detectors 151
    • 6.2.2.1.3 Fluorescence detectors 152
    • 6.2.2.1.4 Mass liquid chromatography detectors 154
    • 6.2.2.1.5 Other liquid chromatography detectors 155
    • 6.2.2.2 Gas chromatography detectors 156
    • 6.2.2.2.1 Flame ionization detectors (FID) 159
    • 6.2.2.2.2 Mass gc detectors 161
    • 6.2.2.2.3 Thermal conductivity detector (tcd) 162
    • 6.2.2.2.4 Other gas chromatography detectors 164
    • 6.2.2.3 SFC detectors 165
  • 6.2.3 PUMPS 166
  • 6.2.4 OTHER INSTRUMENTS 170
• 6.3 CONSUMABLES 173
  • 6.3.1 COLUMNS 176
    • 6.3.1.1 Columns by technology 180
    • 6.3.1.1.1 Liquid chromatography columns 180
    • 6.3.1.1.2 Gas chromatography columns 195
    • 6.3.1.1.3 SFC columns 197
    • 6.3.1.2 Columns by packing type 199
    • 6.3.1.2.1 Pre-packed columns 202
    • 6.3.1.2.2 Empty columns 204
    • 6.3.2 REAGENTS 207
      • 6.3.2.1 Solvents 210
      • 6.3.2.2 Buffers 213
      • 6.3.2.3 Derivatization reagent 215
      • 6.3.2.4 Ion-pair reagents 218
    • 6.3.3 RESINS 221
      • 6.3.3.1 Ion exchange (IEX) chromatography resins 225
      • 6.3.3.2 Affinity chromatography resins 228
      • 6.3.3.2.1 Protein A affinity resins 232
      • 6.3.3.2.2 Protein G affinity resins 234
      • 6.3.3.2.3 Protein L affinity resins 235
      • 6.3.3.2.4 Imobilized metal affinity chromatography (IMAC) resins 236
      • 6.3.3.2.5 Others 237
      • 6.3.3.3 Hydrophobic interaction chromatography (HIC) resins 239
      • 6.3.3.4 Size exclusion chromatography (SFC) resins 241
      • 6.3.3.5 Multimodal chromatography resins 243
    • 6.3.4 OTHER CONSUMBALES 245
  • 6.4 SOFTWARE AND SERVICES 248

  7 CHROMATOGRAPHY GLOBAL MARKET, BY APPLICATION 251

  • 7.1 INTRODUCTION 251
  • 7.2 PHARMA AND BIOTECH INDUSTRY 253
  • 7.3 FOOD AND BEVERAGE INDUSTRY 257
  • 7.4 ENVIRONMENTAL APPLICATION 260
  • 7.5 AGRICULTURE AND CHEMICAL INDUSTRY 262
  • 7.6 OIL AND PETROLEUM INDUSTRY 265
  • 7.7 OTHERS (COSMETICS, FORENSIC TOXICOLOGY) 267

  8 REGIONAL MARKET ANALYSIS 270

  • 8.1 INTRODUCTION 270
  • 8.2 NORTH AMERICA 272
    • 8.2.1 U.S. 296
    • 8.2.2 OTHERS 300
  • 8.3 EUROPE 304
    • 8.3.1 GERMANY 329
    • 8.3.2 FRANCE 334
    • 8.3.3 U.K. 337
    • 8.3.4 OTHERS 341
  • 8.4 ASIA 346
    • 8.4.1 CHINA 369
    • 8.4.2 JAPAN 375
    • 8.4.3 INDIA 379
    • 8.4.4 OTHERS 383
  • 8.5 REST OF THE WORLD (ROW) 388
    • 8.5.1 BRAZIL 411
    • 8.5.2 REST OF LATIN AMERICA 415
    • 8.5.3 MIDDLE EAST AND OTHER COUNTRIES 419

  9 COMPETITIVE LANDSCAPE 424

  • 9.1 INTRODUCTION 424
  • 9.2 NEW PRODUCT LAUNCHES 425
  • 9.3 AGREEMENTS, PARTNERSHIP, COLLABORATION & JOINT VENTURES 441
  • 9.4 APPROVALS 443
  • 9.5 MERGERS & ACQUISITIONS 444
  • 9.6 OTHER DEVELOPMENTS 446

  10 MAJOR COMPANIES 449

  • 10.1 AGILENT TECHNOLOGIES 449
    • 10.1.1 OVERVIEW 449
    • 10.1.2 FINANCIALS 450
    • 10.1.3 PRODUCT PORTFOLIO 452
    • 10.1.4 KEY DEVELOPMENTS 472
    • 10.1.5 BUSINESS STRATEGY 474
    • 10.1.6 SWOT ANALYSIS 475
  • 10.2 BIO-RAD LABORATORIES 476
    • 10.2.1 OVERVIEW 476
    • 10.2.2 FINANCIALS 477
    • 10.2.3 PRODUCT PORTFOLIO 479
    • 10.2.4 KEY DEVELOPMENTS 491
    • 10.2.5 BUSINESS STRATEGY 491
    • 10.2.6 SWOT ANALYSIS 492
  • 10.3 BRUKER CORPORATION 493
    • 10.3.1 OVERVIEW 493
    • 10.3.2 FINANCIALS 494
    • 10.3.3 PRODUCT PORTFOLIO 496
    • 10.3.4 KEY DEVELOPMENTS 497
    • 10.3.5 BUSINESS STRATEGY 503
    • 10.3.6 SWOT ANALYSIS 504
  • 10.4 DANAHER CORPORATION 505
    • 10.4.1 OVERVIEW 505
    • 10.4.2 FINANCIALS 506
    • 10.4.3 PRODUCT PORTFOLIO 508
    • 10.4.4 KEY DEVELOPMENTS 519
    • 10.4.5 BUSINESS STRATEGY 524
    • 10.4.6 SWOT ANALYSIS 525
  • 10.5 GE (GENERAL ELECTRIC COMPANY) 526
    • 10.5.1 OVERVIEW 526
    • 10.5.2 FINANCIALS 527
    • 10.5.3 PRODUCT PORTFOLIO 530
    • 10.5.4 KEY DEVELOPMENTS 532
    • 10.5.5 BUSINESS STRATEGY 534
    • 10.5.6 SWOT ANALYSIS 535
  • 10.6 MERCK KGAA 536
    • 10.6.1 OVERVIEW 536
    • 10.6.2 FINANCIALS 537
    • 10.6.3 PRODUCT PORTFOLIO 540
    • 10.6.4 KEY DEVELOPMENTS 542
    • 10.6.5 BUSINESS STRATEGY 544
    • 10.6.6 SWOT ANALYSIS 545
  • 10.7 PERKINELMER, INC. 546
    • 10.7.1 OVERVIEW 546
    • 10.7.2 FINANCIALS 547
    • 10.7.3 PRODUCT PORTFOLIO 549
    • 10.7.4 KEY DEVELOPMENTS 551
    • 10.7.5 BUSINESS STRATEGY 552
    • 10.7.6 SWOT ANALYSIS 554
  • 10.8 SHIMADZU CORPORATION 555
    • 10.8.1 OVERVIEW 555
    • 10.8.2 FINANCIALS 556
    • 10.8.3 PRODUCT PORTFOLIO 558
    • 10.8.4 KEY DEVELOPMENTS 562
    • 10.8.5 BUSINESS STRATEGY 568
    • 10.8.6 SWOT ANALYSIS 569
  • 10.9 THERMO FISHER SCIENTIFIC 570
    • 10.9.1 OVERVIEW 570
    • 10.9.2 FINANCIALS 571
    • 10.9.3 PRODUCT PORTFOLIO 573
    • 10.9.4 KEY DEVELOPMENTS 580
    • 10.9.5 BUSINESS STRATEGY 583
    • 10.9.6 SWOT ANALYSIS 584
  • 10.10 WATERS CORPORATION 585
    • 10.10.1 OVERVIEW 585
    • 10.10.2 FINANCIALS 586
    • 10.10.3 PRODUCT PORTFOLIO 589
    • 10.10.4 KEY DEVELOPMENTS 594
    • 10.10.5 BUSINESS STRATEGY 598