Report Detail

Pharmaceuticals Cytokine Release Syndrome – Pipeline Insight, 2020

  • RnM4222429
  • |
  • 09 October, 2020
  • |
  • Global
  • |
  • 65 Pages
  • |
  • DelveInsight
  • |
  • Pharmaceuticals

Introduction

    Executive Summary

      Cytokine Release Syndrome: Overview

        • Causes

          • Mechanism of Action

            • Signs and Symptoms

              • Diagnosis

                • Disease Management

                  Pipeline Therapeutics

                    • Comparative Analysis

                      Therapeutic Assessment

                        • Assessment by Product Type

                          • Assessment by Stage and Product Type

                            • Assessment by Route of Administration

                              • Assessment by Stage and Route of Administration

                                • Assessment by Molecule Type

                                  • Assessment by Stage and Molecule Type

                                    Cytokine Release Syndrome – DelveInsight’s Analytical Perspective

                                      In-depth Commercial Assessment

                                        • Cytokine Release Syndrome companies’ collaborations, Licensing, Acquisition -Deal Value Trends

                                          Cytokine Release Syndrome Collaboration Deals

                                            • Company-Company Collaborations (Licensing / Partnering) Analysis

                                              • Company-University Collaborations (Licensing / Partnering) Analysis

                                                Late Stage Products (Phase III)

                                                  • Comparative Analysis

                                                    Canakinumab: Novartis

                                                      • Product Description

                                                        • Research and Development

                                                          • Product Development Activities

                                                            Mid Stage Products (Phase II)

                                                              • Comparative Analysis

                                                                Itacitinib: Incyte Corporation

                                                                  • Product Description

                                                                    • Research and Development

                                                                      • Product Development Activities

                                                                        Dapansutrile: Olatec Therapeutics LLC

                                                                          • Product Description

                                                                            • Research and Development

                                                                              • Product Development Activities

                                                                                Drug profiles in the detailed report…..

                                                                                  Early Stage Products (Phase I)

                                                                                    • Comparative Analysis

                                                                                      Drug Name: Company Name

                                                                                        • Product Description

                                                                                          • Research and Development

                                                                                            • Product Development Activities

                                                                                              Drug profiles in the detailed report…..

                                                                                                Pre-clinical and Discovery Stage Products

                                                                                                  • Comparative Analysis

                                                                                                    Drug Name: Company Name

                                                                                                      • Product Description

                                                                                                        • Research and Development

                                                                                                          • Product Development Activities

                                                                                                            Inactive Products

                                                                                                              • Comparative Analysis

                                                                                                                Cytokine Release Syndrome Key Companies

                                                                                                                  Cytokine Release Syndrome Key Products

                                                                                                                    Cytokine Release Syndrome- Unmet Needs

                                                                                                                      Cytokine Release Syndrome- Market Drivers and Barriers

                                                                                                                        Cytokine Release Syndrome- Future Perspectives and Conclusion

                                                                                                                          Cytokine Release Syndrome Analyst Views

                                                                                                                            Cytokine Release Syndrome Key Companies

                                                                                                                              Appendix

                                                                                                                              DelveInsight’s, “Cytokine Release Syndrome – Pipeline Insight, 2020,” report provides comprehensive insights about 5+ companies and 5+ pipeline drugs in Cytokine Release Syndrome pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.
                                                                                                                              Geography Covered
                                                                                                                              • Global coverage
                                                                                                                              Cytokine Release Syndrome Understanding
                                                                                                                              Cytokine Release Syndrome: Overview
                                                                                                                              A condition that may occur after treatment with some types of immunotherapy, such as monoclonal antibodies and CAR-T cells. Cytokine release syndrome is caused by a large, rapid release of cytokines into the blood from immune cells affected by the immunotherapy. Cytokines are immune substances that have many different actions in the body.
                                                                                                                              Symptoms
                                                                                                                              Signs and symptoms of cytokine release syndrome include fever, nausea, headache, rash, rapid heartbeat, low blood pressure, and trouble breathing. Most patients have a mild reaction, but sometimes, the reaction may be severe or life threatening.
                                                                                                                              Treatment
                                                                                                                              As immune-based therapies for cancer become potent, more effective, and more widely available, optimal management of their unique toxicities becomes increasingly important. Cytokine release syndrome (CRS) is a potentially life-threatening toxicity that has been observed following administration of natural and bispecific antibodies and, more recently, following adoptive T-cell therapies for cancer. CRS is associated with elevated circulating levels of several cytokines including interleukin (IL)-6 and interferon γ, and uncontrolled studies demonstrate that immunosuppression using tocilizumab, an anti-IL-6 receptor antibody, with or without corticosteroids, can reverse the syndrome.
                                                                                                                              Cytokine Release Syndrome Emerging Drugs Chapters
                                                                                                                              This segment of the Cytokine Release Syndrome report encloses its detailed analysis of various drugs in different stages of clinical development, including phase II, I, preclinical and Discovery. It also helps to understand clinical trial details, expressive pharmacological action, agreements and collaborations, and the latest news and press releases.
                                                                                                                              Cytokine Release Syndrome Emerging Drugs
                                                                                                                              • Canakinumab: Novartis
                                                                                                                              Canakinumab is an interleukin (IL)-1β blocker indicated to treat certain periodic fever syndromes, such as cryopyrin-associated periodic syndromes and systemic juvenile idiopathic arthritis. Novartis is conducting phase III trial, called CAN-COVID which will evaluate the drug’s efficacy in treating a type of severe immune overreaction called cytokine release syndrome (CRS) related to Covid-19 pneumonia.
                                                                                                                              • Itacitinib: Incyte Corporation
                                                                                                                              Itacitinib is a potent, selective JAK1 inhibitor which is being clinically evaluated in several inflammatory diseases. It is currently being evaluated in phase II stage for the prevention of Cytokine Release Syndrome Induced by Immune Effector Cell Therapy.
                                                                                                                              • Dapansutrile: Olatec Therapeutics LLC
                                                                                                                              Dapansutrile is being developed by Olatec Therapeutics LLC for the treatment of Cytokine Release Syndrome. It is currently being evaluated in phase II trial to determine safety and efficacy of Dapansutrile for treatment of moderate COVID-19 symptoms and evidence of Early Cytokine Release Syndrome.
                                                                                                                              Further product details are provided in the report……..
                                                                                                                              Cytokine Release Syndrome: Therapeutic Assessment
                                                                                                                              This segment of the report provides insights about the different Cytokine Release Syndrome drugs segregated based on following parameters that define the scope of the report, such as:
                                                                                                                              • Major Players in Cytokine Release Syndrome
                                                                                                                              There are approx. 5+ key companies which are developing the therapies for Cytokine Release Syndrome. The companies which have their Cytokine Release Syndrome drug candidates in the most advanced stage, i.e. phase III include Novartis and others
                                                                                                                              • Phases
                                                                                                                              DelveInsight’s report covers around 5+ products under different phases of clinical development like
                                                                                                                              • Late-stage products (Phase III)
                                                                                                                              • Mid-stage products (Phase II)
                                                                                                                              • Early-stage products (Phase I) along with the details of
                                                                                                                              • Pre-clinical and Discovery stage candidates
                                                                                                                              • Discontinued & Inactive candidates

                                                                                                                              • Route of Administration
                                                                                                                              Cytokine Release Syndrome pipeline report provides the therapeutic assessment of the pipeline drugs by the Route of Administration. Products have been categorized under various ROAs such as
                                                                                                                              • Infusion
                                                                                                                              • Intradermal
                                                                                                                              • Intramuscular
                                                                                                                              • Intranasal
                                                                                                                              • Intravenous
                                                                                                                              • Oral
                                                                                                                              • Parenteral
                                                                                                                              • Subcutaneous

                                                                                                                              • Molecule Type
                                                                                                                              Products have been categorized under various Molecule types such as
                                                                                                                              • Gene therapies
                                                                                                                              • Small molecule
                                                                                                                              • Vaccines
                                                                                                                              • Polymers
                                                                                                                              • Peptides
                                                                                                                              • Monoclonal antibodies

                                                                                                                              • Product Type
                                                                                                                              Drugs have been categorized under various product types like Mono, Combination and Mono/Combination.

                                                                                                                              Cytokine Release Syndrome: Pipeline Development Activities
                                                                                                                              The report provides insights into different therapeutic candidates in phase III, II, I, preclinical and discovery stage. It also analyses Cytokine Release Syndrome therapeutic drugs key players involved in developing key drugs.
                                                                                                                              Pipeline Development Activities
                                                                                                                              The report covers the detailed information of collaborations, acquisition and merger, licensing along with a thorough therapeutic assessment of emerging Cytokine Release Syndrome drugs.

                                                                                                                              Report Highlights
                                                                                                                              • The companies and academics are working to assess challenges and seek opportunities that could influence Cytokine Release Syndrome R&D. The therapies under development are focused on novel approaches to treat/improve Cytokine Release Syndrome.
                                                                                                                              • In July 2020, India's medical authorities approve Biocon Biologic's itolizumab, an anti-CD6 IgG1 monoclonal antibody, for emergency treatment of cytokine release syndrome in patients with coronavirus disease 2019 (COVID-19).
                                                                                                                              Cytokine Release Syndrome Report Insights
                                                                                                                              • Cytokine Release Syndrome Pipeline Analysis
                                                                                                                              • Therapeutic Assessment
                                                                                                                              • Unmet Needs
                                                                                                                              • Impact of Drugs
                                                                                                                              Cytokine Release Syndrome Report Assessment
                                                                                                                              • Pipeline Product Profiles
                                                                                                                              • Therapeutic Assessment
                                                                                                                              • Pipeline Assessment
                                                                                                                              • Inactive drugs assessment
                                                                                                                              • Unmet Needs

                                                                                                                              Key Questions
                                                                                                                              Current Treatment Scenario and Emerging Therapies:
                                                                                                                              • How many companies are developing Cytokine Release Syndrome drugs?
                                                                                                                              • How many Cytokine Release Syndrome drugs are developed by each company?
                                                                                                                              • How many emerging drugs are in mid-stage, and late-stage of development for the treatment of Cytokine Release Syndrome?
                                                                                                                              • What are the key collaborations (Industry–Industry, Industry–Academia), Mergers and acquisitions, licensing activities related to the Cytokine Release Syndrome therapeutics?
                                                                                                                              • What are the recent trends, drug types and novel technologies developed to overcome the limitation of existing therapies?
                                                                                                                              • What are the clinical studies going on for Cytokine Release Syndrome and their status?
                                                                                                                              • What are the key designations that have been granted to the emerging drugs?
                                                                                                                              Key Players
                                                                                                                              • Biocon Limited
                                                                                                                              • Olatec Therapeutics LLC
                                                                                                                              • Novartis Pharmaceuticals

                                                                                                                              Key Products
                                                                                                                              • Itacitinib
                                                                                                                              • Dapansutrile
                                                                                                                              • Canakinumab
                                                                                                                              • Ruxolitinib


                                                                                                                              Summary:
                                                                                                                              Get latest Market Research Reports on Cytokine Release Syndrome. Industry analysis & Market Report on Cytokine Release Syndrome is a syndicated market report, published as Cytokine Release Syndrome – Pipeline Insight, 2020. It is complete Research Study and Industry Analysis of Cytokine Release Syndrome market, to understand, Market Demand, Growth, trends analysis and Factor Influencing market.

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