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Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Pipeline Review, H1 2019

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Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Overview

              Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Therapeutics Development

                Products under Development by Stage of Development

                  Products under Development by Therapy Area

                    Products under Development by Indication

                      Products under Development by Companies

                        Products under Development by Universities/Institutes

                          Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Therapeutics Assessment

                            Assessment by Mechanism of Action

                              Assessment by Route of Administration

                                Assessment by Molecule Type

                                  Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Companies Involved in Therapeutics Development

                                    AbbVie Inc

                                      Abeome Corp

                                        Alligator Bioscience AB

                                          Apogenix AG

                                            BioInvent International AB

                                              Bristol-Myers Squibb Co

                                                Denceptor Therapeutics Ltd

                                                  GigaGen Inc

                                                    GlaxoSmithKline Plc

                                                      Incyte Corp

                                                        Innovent Biologics Inc

                                                          Invenra Inc

                                                            Johnson & Johnson

                                                              Kyowa Hakko Kirin Co Ltd

                                                                Pfizer Inc

                                                                  Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Drug Profiles

                                                                    ABBV-368 - Drug Profile

                                                                      Product Description

                                                                        Mechanism Of Action

                                                                          R&D Progress

                                                                            ABM-193 - Drug Profile

                                                                              Product Description

                                                                                Mechanism Of Action

                                                                                  R&D Progress

                                                                                    AP-201 - Drug Profile

                                                                                      Product Description

                                                                                        Mechanism Of Action

                                                                                          R&D Progress

                                                                                            ATOR-1015 - Drug Profile

                                                                                              Product Description

                                                                                                Mechanism Of Action

                                                                                                  R&D Progress

                                                                                                    Bispecific Monoclonal Antibodies to Agonize FCGR2A, FCGR2B and TNFRSF4 for Methicillin-Resistant Staphylococcus aureus Infections - Drug Profile

                                                                                                      Product Description

                                                                                                        Mechanism Of Action

                                                                                                          R&D Progress

                                                                                                            Bispecific Monoclonal Antibodies to Agonize TNFRSF4 for Oncology - Drug Profile

                                                                                                              Product Description

                                                                                                                Mechanism Of Action

                                                                                                                  R&D Progress

                                                                                                                    BMS-986178 - Drug Profile

                                                                                                                      Product Description

                                                                                                                        Mechanism Of Action

                                                                                                                          R&D Progress

                                                                                                                            Fusion Protein to Agonize OX40 for Solid Tumor - Drug Profile

                                                                                                                              Product Description

                                                                                                                                Mechanism Of Action

                                                                                                                                  R&D Progress

                                                                                                                                    Fusion Proteins to Agonize OX40 and NOTCH1 for Type 1 Diabetes - Drug Profile

                                                                                                                                      Product Description

                                                                                                                                        Mechanism Of Action

                                                                                                                                          R&D Progress

                                                                                                                                            GSK-3174998 - Drug Profile

                                                                                                                                              Product Description

                                                                                                                                                Mechanism Of Action

                                                                                                                                                  R&D Progress

                                                                                                                                                    HuOHX-10 - Drug Profile

                                                                                                                                                      Product Description

                                                                                                                                                        Mechanism Of Action

                                                                                                                                                          R&D Progress

                                                                                                                                                            IBI-101 - Drug Profile

                                                                                                                                                              Product Description

                                                                                                                                                                Mechanism Of Action

                                                                                                                                                                  R&D Progress

                                                                                                                                                                    INCAGN-1949 - Drug Profile

                                                                                                                                                                      Product Description

                                                                                                                                                                        Mechanism Of Action

                                                                                                                                                                          R&D Progress

                                                                                                                                                                            KHK-4083 - Drug Profile

                                                                                                                                                                              Product Description

                                                                                                                                                                                Mechanism Of Action

                                                                                                                                                                                  R&D Progress

                                                                                                                                                                                    Monoclonal Antibodies to Agonize OX40 for Oncology - Drug Profile

                                                                                                                                                                                      Product Description

                                                                                                                                                                                        Mechanism Of Action

                                                                                                                                                                                          R&D Progress

                                                                                                                                                                                            Monoclonal Antibodies to Agonize OX40L Receptor for Oncology - Drug Profile

                                                                                                                                                                                              Product Description

                                                                                                                                                                                                Mechanism Of Action

                                                                                                                                                                                                  R&D Progress

                                                                                                                                                                                                    Monoclonal Antibody Conjugate to Target OX40L for Transplant Rejection - Drug Profile

                                                                                                                                                                                                      Product Description

                                                                                                                                                                                                        Mechanism Of Action

                                                                                                                                                                                                          R&D Progress

                                                                                                                                                                                                            Monoclonal Antibody to Agonize OX40 for Hematological Tumor and Solid Tumor - Drug Profile

                                                                                                                                                                                                              Product Description

                                                                                                                                                                                                                Mechanism Of Action

                                                                                                                                                                                                                  R&D Progress

                                                                                                                                                                                                                    Monoclonal Antibody to Antagonize OX40 for Oncology - Drug Profile

                                                                                                                                                                                                                      Product Description

                                                                                                                                                                                                                        Mechanism Of Action

                                                                                                                                                                                                                          R&D Progress

                                                                                                                                                                                                                            MSB-013 - Drug Profile

                                                                                                                                                                                                                              Product Description

                                                                                                                                                                                                                                Mechanism Of Action

                                                                                                                                                                                                                                  R&D Progress

                                                                                                                                                                                                                                    OrthomAb - Drug Profile

                                                                                                                                                                                                                                      Product Description

                                                                                                                                                                                                                                        Mechanism Of Action

                                                                                                                                                                                                                                          R&D Progress

                                                                                                                                                                                                                                            PF-04518600 - Drug Profile

                                                                                                                                                                                                                                              Product Description

                                                                                                                                                                                                                                                Mechanism Of Action

                                                                                                                                                                                                                                                  R&D Progress

                                                                                                                                                                                                                                                    SCB-340 - Drug Profile

                                                                                                                                                                                                                                                      Product Description

                                                                                                                                                                                                                                                        Mechanism Of Action

                                                                                                                                                                                                                                                          R&D Progress

                                                                                                                                                                                                                                                            SL-279252 - Drug Profile

                                                                                                                                                                                                                                                              Product Description

                                                                                                                                                                                                                                                                Mechanism Of Action

                                                                                                                                                                                                                                                                  R&D Progress

                                                                                                                                                                                                                                                                    Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Dormant Products

                                                                                                                                                                                                                                                                      Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Discontinued Products

                                                                                                                                                                                                                                                                        Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Product Development Milestones

                                                                                                                                                                                                                                                                          Featured News & Press Releases

                                                                                                                                                                                                                                                                            Apr 11, 2019: Alligator Bioscience: Preclinical data on the tumor-localizing anti-CTLA-4 antibody ATOR-1015 published in the Journal for ImmunoTherapy of Cancer

                                                                                                                                                                                                                                                                              Apr 10, 2019: Alligator Bioscience to present new preclinical data on ATOR-1015 at PEGS Boston

                                                                                                                                                                                                                                                                                Mar 07, 2019: Alligator Bioscience: First patient dosed in phase I study of ATOR-1015

                                                                                                                                                                                                                                                                                  Feb 20, 2019: GigaGen Publishes Study Demonstrating Optimal Method for Selecting OX40 Therapeutic Candidates from Antibody Repertoires

                                                                                                                                                                                                                                                                                    Feb 14, 2019: Innovent starts treatment in IBI101 monoclonal antibody trial

                                                                                                                                                                                                                                                                                      Dec 11, 2018: Alligator Bioscience starts clinical phase I study with ATOR-1015

                                                                                                                                                                                                                                                                                        Dec 04, 2018: Innovent receives an approval from the US FDA to initiate clinical trials for its Anti-OX40 Monoclonal Antibody IBI101

                                                                                                                                                                                                                                                                                          Jul 25, 2018: Innovent receives IND approval to initiate clinical trials in china with its anti-OX40 Agonistic Antibody IBI101

                                                                                                                                                                                                                                                                                            Jul 19, 2018: Alligator Bioscience submits application to start clinical phase I study in cancer patients with ATOR-1015, a unique CTLA-4 and OX40 binding antibody

                                                                                                                                                                                                                                                                                              Apr 17, 2018: Alligator Bioscience presents ATOR-1015 preclinical data at the AACR Annual Meeting 2018 confirming localized tumor activation

                                                                                                                                                                                                                                                                                                Jan 25, 2018: Alligator Bioscience contracts Theradex Oncology as clinical CRO for the forthcoming Phase I study with ATOR-1015

                                                                                                                                                                                                                                                                                                  Jul 08, 2017: Alligator contracts BioInvent for process development and cGMP manufacturing of the immuno-oncology drug candidate ADC-1015

                                                                                                                                                                                                                                                                                                    May 04, 2017: Alligator Bioscience presents promising immuno-oncology data at US conference; - Strong new preclinical findings for ATOR-1015

                                                                                                                                                                                                                                                                                                      Apr 28, 2017: Alligator Bioscience to present new pre-clinical data for ATOR-1015 at PEGS conference in Boston, May 4

                                                                                                                                                                                                                                                                                                        Mar 07, 2017: Agenus Abstract Accepted for Presentation on INCAGN01949 at the American Association for Cancer Research (AACR) 2017 Annual Meeting

                                                                                                                                                                                                                                                                                                          Appendix

                                                                                                                                                                                                                                                                                                            Methodology

                                                                                                                                                                                                                                                                                                              Coverage

                                                                                                                                                                                                                                                                                                                Secondary Research

                                                                                                                                                                                                                                                                                                                  Primary Research

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                                                                                                                                                                                                                                                                                                                        Disclaimer

                                                                                                                                                                                                                                                                                                                        Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Pipeline Review, H1 2019

                                                                                                                                                                                                                                                                                                                        Summary

                                                                                                                                                                                                                                                                                                                        Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) pipeline Target constitutes close to 24 molecules. Out of which approximately 23 molecules are developed by companies and remaining by the universities/institutes. The latest report Tumor Necrosis Factor Receptor Superfamily Member 4 - Pipeline Review, H1 2019, outlays comprehensive information on the Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type.

                                                                                                                                                                                                                                                                                                                        Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) - Tumor Necrosis Factor Receptor Superfamily Member 4 or OX40 is a member of the TNF-receptor superfamily. This receptor has been shown to activate NF-kappaB through its interaction with adaptor proteins TRAF2 and TRAF5. OX40L binds to OX40 receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40 also plays a crucial role in both Th1 and Th2 mediated reactions. The molecules developed by companies in Phase II, Phase I, IND/CTA Filed, Preclinical and Discovery stages are 5, 4, 1, 5 and 8 respectively.

                                                                                                                                                                                                                                                                                                                        Similarly, the universities portfolio in Preclinical stages comprises 1 molecules, respectively. Report covers products from therapy areas Oncology, Infectious Disease, Dermatology, Gastrointestinal, Immunology and Metabolic Disorders which include indications Solid Tumor, Head And Neck Cancer Squamous Cell Carcinoma, Melanoma, Non-Small Cell Lung Cancer, Cervical Cancer, Bladder Cancer, Breast Cancer, Colorectal Cancer, Gastric Cancer, Head And Neck Cancer, Hematological Tumor, Lung Cancer, Metastatic Melanoma, Renal Cell Carcinoma, Transitional Cell Carcinoma (Urothelial Cell Carcinoma), Acral Lentiginous Melanoma, Adenocarcinoma Of The Gastroesophageal Junction, Atopic Dermatitis (Atopic Eczema), B-Cell Non-Hodgkin Lymphoma, Colon Cancer, Diffuse Large B-Cell Lymphoma, Endometrial Cancer, Esophageal Cancer, Follicular Lymphoma, Hepatitis B, Hodgkin Lymphoma (B-Cell Hodgkin Lymphoma), Hypopharyngeal Cancer, Kidney Cancer (Renal Cell Cancer), Laryngeal Cancer, Malignant Pleural Mesothelioma, Metastatic Breast Cancer, Metastatic Cancer, Metastatic Hepatocellular Carcinoma (HCC), Metastatic Ovarian Cancer, Metastatic Renal Cell Carcinoma, Metastatic Transitional (Urothelial) Tract Cancer, Methicillin-Resistant Staphylococcus aureus (MRSA) Infections, Ocular Melanoma, Oral Cavity (Mouth) Cancer, Oropharyngeal Cancer, Pancreatic Cancer, Prostate Cancer, Refractory Acute Myeloid Leukemia, Relapsed Acute Myeloid Leukemia, Soft Tissue Sarcoma, Squamous Cell Carcinoma, Squamous Non-Small Cell Lung Cancer, Transplant Rejection, Type 1 Diabetes (Juvenile Diabetes), Ulcerative Colitis and Uterine Cancer.

                                                                                                                                                                                                                                                                                                                        Furthermore, this report also reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics development with respective active and dormant or discontinued projects. Driven by data and information sourced from proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources.

                                                                                                                                                                                                                                                                                                                        Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

                                                                                                                                                                                                                                                                                                                        Scope

                                                                                                                                                                                                                                                                                                                        - The report provides a snapshot of the global therapeutic landscape for Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4)
                                                                                                                                                                                                                                                                                                                        - The report reviews Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
                                                                                                                                                                                                                                                                                                                        - The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
                                                                                                                                                                                                                                                                                                                        - The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
                                                                                                                                                                                                                                                                                                                        - The report reviews key players involved in Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics and enlists all their major and minor projects
                                                                                                                                                                                                                                                                                                                        - The report assesses Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
                                                                                                                                                                                                                                                                                                                        - The report summarizes all the dormant and discontinued pipeline projects
                                                                                                                                                                                                                                                                                                                        - The report reviews latest news and deals related to Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4) targeted therapeutics

                                                                                                                                                                                                                                                                                                                        Reasons to buy

                                                                                                                                                                                                                                                                                                                        - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
                                                                                                                                                                                                                                                                                                                        - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
                                                                                                                                                                                                                                                                                                                        - Identify and understand the targeted therapy areas and indications for Tumor Necrosis Factor Receptor Superfamily Member 4 (ACT35 Antigen or TAX Transcriptionally Activated Glycoprotein 1 Receptor or OX40L Receptor or CD134 or TNFRSF4)
                                                                                                                                                                                                                                                                                                                        - Identify the use of drugs for target identification and drug repurposing
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                                                                                                                                                                                                                                                                                                                        - Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
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