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Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Pipeline Review, H1 2019

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Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Overview

              Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Therapeutics Development

                Products under Development by Stage of Development

                  Products under Development by Therapy Area

                    Products under Development by Indication

                      Products under Development by Companies

                        Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Therapeutics Assessment

                          Assessment by Mechanism of Action

                            Assessment by Route of Administration

                              Assessment by Molecule Type

                                Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Companies Involved in Therapeutics Development

                                  3SBio Inc

                                    Bausch Health Companies Inc

                                      Boehringer Ingelheim GmbH

                                        Galderma SA

                                          Ipsen SA

                                            Lee's Pharmaceutical Holdings Ltd

                                              Phosphagenics Ltd

                                                Promius Pharma LLC

                                                  Sol-Gel Technologies Ltd

                                                    Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Drug Profiles

                                                      (adapalene + benzoyl peroxide + clindamycin phosphate) - Drug Profile

                                                        Product Description

                                                          Mechanism Of Action

                                                            R&D Progress

                                                              (adapalene + clindamycin hydrochloride) - Drug Profile

                                                                Product Description

                                                                  Mechanism Of Action

                                                                    R&D Progress

                                                                      (benzoyl peroxide + tretinoin) - Drug Profile

                                                                        Product Description

                                                                          Mechanism Of Action

                                                                            R&D Progress

                                                                              (benzoyl peroxide + tretinoin) - Drug Profile

                                                                                Product Description

                                                                                  Mechanism Of Action

                                                                                    R&D Progress

                                                                                      (clindamycin phosphate + tretinoin) - Drug Profile

                                                                                        Product Description

                                                                                          Mechanism Of Action

                                                                                            R&D Progress

                                                                                              (TPX-6001 + tretinoin) - Drug Profile

                                                                                                Product Description

                                                                                                  Mechanism Of Action

                                                                                                    R&D Progress

                                                                                                      alitretinoin - Drug Profile

                                                                                                        Product Description

                                                                                                          Mechanism Of Action

                                                                                                            R&D Progress

                                                                                                              bexarotene + CD-1530 - Drug Profile

                                                                                                                Product Description

                                                                                                                  Mechanism Of Action

                                                                                                                    R&D Progress

                                                                                                                      palovarotene - Drug Profile

                                                                                                                        Product Description

                                                                                                                          Mechanism Of Action

                                                                                                                            R&D Progress

                                                                                                                              Small Molecule to Antagonize ROR-Gamma for Autoimmune and Allergic Disorders - Drug Profile

                                                                                                                                Product Description

                                                                                                                                  Mechanism Of Action

                                                                                                                                    R&D Progress

                                                                                                                                      Small Molecules 1 to Agonize Retinoic Acid Receptor Gamma for Musculoskeletal Disorders - Drug Profile

                                                                                                                                        Product Description

                                                                                                                                          Mechanism Of Action

                                                                                                                                            R&D Progress

                                                                                                                                              Small Molecules to Agonize RARG for Fibrosis - Drug Profile

                                                                                                                                                Product Description

                                                                                                                                                  Mechanism Of Action

                                                                                                                                                    R&D Progress

                                                                                                                                                      Small Molecules to Agonize Retinoic Acid Receptor Gamma for Musculoskeletal Disorders - Drug Profile

                                                                                                                                                        Product Description

                                                                                                                                                          Mechanism Of Action

                                                                                                                                                            R&D Progress

                                                                                                                                                              tazarotene - Drug Profile

                                                                                                                                                                Product Description

                                                                                                                                                                  Mechanism Of Action

                                                                                                                                                                    R&D Progress

                                                                                                                                                                      tazarotene - Drug Profile

                                                                                                                                                                        Product Description

                                                                                                                                                                          Mechanism Of Action

                                                                                                                                                                            R&D Progress

                                                                                                                                                                              tretinoin - Drug Profile

                                                                                                                                                                                Product Description

                                                                                                                                                                                  Mechanism Of Action

                                                                                                                                                                                    R&D Progress

                                                                                                                                                                                      tretinoin - Drug Profile

                                                                                                                                                                                        Product Description

                                                                                                                                                                                          Mechanism Of Action

                                                                                                                                                                                            R&D Progress

                                                                                                                                                                                              trifarotene - Drug Profile

                                                                                                                                                                                                Product Description

                                                                                                                                                                                                  Mechanism Of Action

                                                                                                                                                                                                    R&D Progress

                                                                                                                                                                                                      vitamin A palmitate - Drug Profile

                                                                                                                                                                                                        Product Description

                                                                                                                                                                                                          Mechanism Of Action

                                                                                                                                                                                                            R&D Progress

                                                                                                                                                                                                              vitamin A palmitate - Drug Profile

                                                                                                                                                                                                                Product Description

                                                                                                                                                                                                                  Mechanism Of Action

                                                                                                                                                                                                                    R&D Progress

                                                                                                                                                                                                                      Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Dormant Products

                                                                                                                                                                                                                        Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Discontinued Products

                                                                                                                                                                                                                          Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Product Development Milestones

                                                                                                                                                                                                                            Featured News & Press Releases

                                                                                                                                                                                                                              Apr 15, 2019: Sol-Gel Technologies announces 50% enrollment in pivotal phase III TWIN Program for the treatment of Acne Vulgaris

                                                                                                                                                                                                                                Feb 28, 2019: Galderma Announces Publication of Pivotal Phase 3 PERFECT 1 and PERFECT 2 Clinical Trials of Trifarotene in Patients with Moderate Facial and Truncal Acne in the Journal of the American Academy of Dermatology

                                                                                                                                                                                                                                  Feb 11, 2019: Clementia granted Rare Pediatric Disease Designation by FDA for Palovarotene for Fibrodysplasia Ossificans Progressiva

                                                                                                                                                                                                                                    Dec 17, 2018: Sol-Gel Technologies initiates pivotal phase III clinical program of TWIN for the treatment of acne vulgaris

                                                                                                                                                                                                                                      Oct 30, 2018: Bausch Health launches ALTRENO (tretinoin) Lotion, 0.05% in the United States

                                                                                                                                                                                                                                        Oct 23, 2018: Clementia announces plan to submit a new drug application for Palovarotene for the treatment of FOP based on positive phase 2 results

                                                                                                                                                                                                                                          Oct 15, 2018: Bausch Health's ortho dermatologics business to present on ALTRENO During The Fall Clinical Dermatology Conference

                                                                                                                                                                                                                                            Oct 11, 2018: Bausch Health announces publication of pivotal phase 3 efficacy and safety data on ALTRENO (tretinoin) Lotion, 0.05%, in the journal of drugs in dermatology

                                                                                                                                                                                                                                              Oct 02, 2018: Clementia initiates phase 1 clinical trial of palovarotene eye drop formulation in healthy volunteers

                                                                                                                                                                                                                                                Sep 26, 2018: Clementia announces updated phase 2 part B data on Palovarotene for FOP

                                                                                                                                                                                                                                                  Sep 05, 2018: Clementia to Present at ASBMR 2018 and Upcoming Investor Conferences

                                                                                                                                                                                                                                                    Sep 04, 2018: Sol-Gel Technologies provides program update for TWIN for the treatment of acne vulgaris

                                                                                                                                                                                                                                                      Aug 24, 2018: Ortho Dermatologics receives FDA approval for Altreno (tretinoin 0.05%) lotion for acne

                                                                                                                                                                                                                                                        Aug 17, 2018: Clementia completes patient enrolment in phase 3 of MOVE Trial

                                                                                                                                                                                                                                                          May 23, 2018: Clementia Reports Positive Phase 2 Part B Data Showing Treatment with Palovarotene Significantly Reduces New Bone Growth in Patients with FOP

                                                                                                                                                                                                                                                            Appendix

                                                                                                                                                                                                                                                              Methodology

                                                                                                                                                                                                                                                                Coverage

                                                                                                                                                                                                                                                                  Secondary Research

                                                                                                                                                                                                                                                                    Primary Research

                                                                                                                                                                                                                                                                      Expert Panel Validation

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                                                                                                                                                                                                                                                                          Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Pipeline Review, H1 2019

                                                                                                                                                                                                                                                                          Summary

                                                                                                                                                                                                                                                                          According to the recently published report 'Retinoic Acid Receptor Gamma - Pipeline Review, H1 2019'; Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) pipeline Target constitutes close to 18 molecules.

                                                                                                                                                                                                                                                                          Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) - Retinoic acid receptor gamma (RARG) is a nuclear receptor that is encoded by the RARG gene. RARG bind as heterodimers to the target response elements in response to their ligands (all-trans or 9-cis retinoic acid) and regulate gene expression in various biological processes. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to co-repressors. It is required for limb bud development.

                                                                                                                                                                                                                                                                          The report 'Retinoic Acid Receptor Gamma - Pipeline Review, H1 2019' outlays comprehensive information on the Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) targeted therapeutics, complete with analysis by indications, stage of development, mechanism of action (MoA), route of administration (RoA) and molecule type; that are being developed by Companies / Universities.

                                                                                                                                                                                                                                                                          It also reviews key players involved in Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) targeted therapeutics development with respective active and dormant or discontinued projects. Currently, The molecules developed by companies in Pre-Registration, Phase III, Phase II, Preclinical and Discovery stages are 1, 7, 2, 7 and 1 respectively.

                                                                                                                                                                                                                                                                          Report covers products from therapy areas Dermatology, Musculoskeletal Disorders, Oncology, Ophthalmology, Respiratory, Gastrointestinal, Genetic Disorders and Immunology which include indications Acne Vulgaris, Bronchopulmonary Dysplasia, Allergies, Autoimmune Disorders, Congenital Ichthyosis, Esophageal Cancer, Fibrodysplasia Ossificans Progressiva (Myositis Ossificans Progressiva), Fibrosis, Gorlin Syndrome (Basal Cell Nevus Syndrome/ Nevoid Basal Cell Carcinoma Syndrome), Head And Neck Cancer, Inflammatory Bowel Disease, Keratoconjunctivitis Sicca (Dry Eye), Multiple Hereditary Exostoses, Retinopathy Of Prematurity and Spondyloarthritis (Spondyloarthropathy).

                                                                                                                                                                                                                                                                          Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

                                                                                                                                                                                                                                                                          Scope

                                                                                                                                                                                                                                                                          - The report provides a snapshot of the global therapeutic landscape for Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG)
                                                                                                                                                                                                                                                                          - The report reviews Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) targeted therapeutics under development by companies and universities/research institutes based on information derived from company and industry-specific sources
                                                                                                                                                                                                                                                                          - The report covers pipeline products based on various stages of development ranging from pre-registration till discovery and undisclosed stages
                                                                                                                                                                                                                                                                          - The report features descriptive drug profiles for the pipeline products which includes, product description, descriptive MoA, R&D brief, licensing and collaboration details & other developmental activities
                                                                                                                                                                                                                                                                          - The report reviews key players involved in Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) targeted therapeutics and enlists all their major and minor projects
                                                                                                                                                                                                                                                                          - The report assesses Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) targeted therapeutics based on mechanism of action (MoA), route of administration (RoA) and molecule type
                                                                                                                                                                                                                                                                          - The report summarizes all the dormant and discontinued pipeline projects
                                                                                                                                                                                                                                                                          - The report reviews latest news and deals related to Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) targeted therapeutics

                                                                                                                                                                                                                                                                          Reasons to buy

                                                                                                                                                                                                                                                                          - Gain strategically significant competitor information, analysis, and insights to formulate effective R&D strategies
                                                                                                                                                                                                                                                                          - Identify emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage
                                                                                                                                                                                                                                                                          - Identify and understand the targeted therapy areas and indications for Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG)
                                                                                                                                                                                                                                                                          - Identify the use of drugs for target identification and drug repurposing
                                                                                                                                                                                                                                                                          - Identify potential new clients or partners in the target demographic
                                                                                                                                                                                                                                                                          - Develop strategic initiatives by understanding the focus areas of leading companies
                                                                                                                                                                                                                                                                          - Plan mergers and acquisitions effectively by identifying key players and it’s most promising pipeline therapeutics
                                                                                                                                                                                                                                                                          - Devise corrective measures for pipeline projects by understanding Retinoic Acid Receptor Gamma (RAR Gamma or Nuclear Receptor Subfamily 1 Group B Member 3 or NR1B3 or RARG) development landscape
                                                                                                                                                                                                                                                                          - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope

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