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Reflux Esophagitis (Gastro esophageal Reflux Disease) - Pipeline Review, H1 2019

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Table of Contents

    List of Tables

      List of Figures

        Introduction

          Global Markets Direct Report Coverage

            Reflux Esophagitis (Gastro esophageal Reflux Disease) - Overview

              Reflux Esophagitis (Gastro esophageal Reflux Disease) - Therapeutics Development

                Pipeline Overview

                  Pipeline by Companies

                    Products under Development by Companies

                      Reflux Esophagitis (Gastro esophageal Reflux Disease) - Therapeutics Assessment

                        Assessment by Target

                          Assessment by Mechanism of Action

                            Assessment by Route of Administration

                              Assessment by Molecule Type

                                Reflux Esophagitis (Gastro esophageal Reflux Disease) - Companies Involved in Therapeutics Development

                                  Ahn-Gook Pharmaceutical Co Ltd

                                    Chong Kun Dang Pharmaceutical Corp

                                      CJ HealthCare Corp

                                        Daewoong Pharmaceutical Co Ltd

                                          Eisai Co Ltd

                                            Handa Pharmaceuticals LLC

                                              Ilyang Pharmaceutical Co Ltd

                                                Ironwood Pharmaceuticals Inc

                                                  Jeil Pharmaceutical Co Ltd

                                                    RaQualia Pharma Inc

                                                      Sam-A Pharm Co Ltd

                                                        Sun Pharma Advanced Research Company Ltd

                                                          Takeda Pharmaceutical Co Ltd

                                                            Yooyoung Pharm Co Ltd

                                                              Yuyu Pharma Inc

                                                                Reflux Esophagitis (Gastro esophageal Reflux Disease) - Drug Profiles

                                                                  (esomeprazole + sodium bicarbonate) - Drug Profile

                                                                    Product Description

                                                                      Mechanism Of Action

                                                                        R&D Progress

                                                                          azeloprazole sodium - Drug Profile

                                                                            Product Description

                                                                              Mechanism Of Action

                                                                                R&D Progress

                                                                                  ceclazepide - Drug Profile

                                                                                    Product Description

                                                                                      Mechanism Of Action

                                                                                        R&D Progress

                                                                                          CG-20043 - Drug Profile

                                                                                            Product Description

                                                                                              Mechanism Of Action

                                                                                                R&D Progress

                                                                                                  CJ-30065 - Drug Profile

                                                                                                    Product Description

                                                                                                      Mechanism Of Action

                                                                                                        R&D Progress

                                                                                                          colesevelam - Drug Profile

                                                                                                            Product Description

                                                                                                              Mechanism Of Action

                                                                                                                R&D Progress

                                                                                                                  dexlansoprazole DR - Drug Profile

                                                                                                                    Product Description

                                                                                                                      Mechanism Of Action

                                                                                                                        R&D Progress

                                                                                                                          DWP-14012 - Drug Profile

                                                                                                                            Product Description

                                                                                                                              Mechanism Of Action

                                                                                                                                R&D Progress

                                                                                                                                  esomeprazole - Drug Profile

                                                                                                                                    Product Description

                                                                                                                                      Mechanism Of Action

                                                                                                                                        R&D Progress

                                                                                                                                          G-17DT - Drug Profile

                                                                                                                                            Product Description

                                                                                                                                              Mechanism Of Action

                                                                                                                                                R&D Progress

                                                                                                                                                  HND-009 - Drug Profile

                                                                                                                                                    Product Description

                                                                                                                                                      Mechanism Of Action

                                                                                                                                                        R&D Progress

                                                                                                                                                          ilaprazole DR - Drug Profile

                                                                                                                                                            Product Description

                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                R&D Progress

                                                                                                                                                                  IYHCR-17 - Drug Profile

                                                                                                                                                                    Product Description

                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                        R&D Progress

                                                                                                                                                                          JP-1366 - Drug Profile

                                                                                                                                                                            Product Description

                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                R&D Progress

                                                                                                                                                                                  naronapride - Drug Profile

                                                                                                                                                                                    Product Description

                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                          netazepide - Drug Profile

                                                                                                                                                                                            Product Description

                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                  pantoprazole - Drug Profile

                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                          pantoprazole DR - Drug Profile

                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                  RQ-00000774 - Drug Profile

                                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                                          SA-15001 - Drug Profile

                                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                                  tegoprazan - Drug Profile

                                                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                                                          vonoprazan - Drug Profile

                                                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                                                  X-842 - Drug Profile

                                                                                                                                                                                                                                                    Product Description

                                                                                                                                                                                                                                                      Mechanism Of Action

                                                                                                                                                                                                                                                        R&D Progress

                                                                                                                                                                                                                                                          YY-DXR - Drug Profile

                                                                                                                                                                                                                                                            Product Description

                                                                                                                                                                                                                                                              Mechanism Of Action

                                                                                                                                                                                                                                                                R&D Progress

                                                                                                                                                                                                                                                                  Reflux Esophagitis (Gastro esophageal Reflux Disease) - Dormant Projects

                                                                                                                                                                                                                                                                    Reflux Esophagitis (Gastro esophageal Reflux Disease) - Discontinued Products

                                                                                                                                                                                                                                                                      Reflux Esophagitis (Gastro esophageal Reflux Disease) - Product Development Milestones

                                                                                                                                                                                                                                                                        Featured News & Press Releases

                                                                                                                                                                                                                                                                          Oct 08, 2018: Ironwood Pharmaceuticals presents IW-3718 data at the American College of Gastroenterology 2018 Annual Scientific Meeting

                                                                                                                                                                                                                                                                            Jul 06, 2018: Ministry approves CJ Healthcares Gastro esophageal reflux treatment

                                                                                                                                                                                                                                                                              Jul 06, 2018: RaQualia Announces Receipt of Milestone Payment from CJ HealthCare

                                                                                                                                                                                                                                                                                Jun 21, 2018: Ironwood begins two Phase III trials of IW-3718

                                                                                                                                                                                                                                                                                  Jun 05, 2018: Ironwood Pharmaceuticals Presents IW-3718 Data Showing Improvements in Heartburn and Regurgitation Symptoms in Patients with Persistent GERD at Digestive Disease Week 2018

                                                                                                                                                                                                                                                                                    Jun 05, 2018: Ironwood Pharmaceuticals Presents IW-3718 Data Showing Improvements in Heartburn and Regurgitation Symptoms in Patients with Persistent GERD at Digestive Disease Week 2018

                                                                                                                                                                                                                                                                                      May 23, 2018: Ironwood Pharmaceuticals to Highlight Clinical Data for IW-3718 in Persistent Gastro esophageal Reflux Disease (GERD) at Digestive Disease Week 2018

                                                                                                                                                                                                                                                                                        Apr 16, 2018: First clinical study successfully completed with X842, an innovative promising treatment for severe erosive GERD

                                                                                                                                                                                                                                                                                          Jul 20, 2017: Ironwood Pharmaceuticals Reports Positive Top-line Results from IW-3718 Phase IIb Trial in Uncontrolled Gastro esophageal Reflux Disease

                                                                                                                                                                                                                                                                                            Mar 09, 2017: Ironwood Pharmaceuticals provides update on key pipeline program IW-3718 at R&D Day 2017

                                                                                                                                                                                                                                                                                              Nov 16, 2016: Renexxion Achieves Positive FDA Guidance for Phase 3-ready GI Drug Naronapride

                                                                                                                                                                                                                                                                                                Jul 11, 2016: Takeda Announces FDA Approval of Dexilant (dexlansoprazole) for Patients 12-17 Years of Age

                                                                                                                                                                                                                                                                                                  Mar 23, 2016: Ironwood Pharmaceuticals Initiates Phase IIb Clinical Trial of IW-3718 in Refractory Gastro esophageal Reflux Disease

                                                                                                                                                                                                                                                                                                    Feb 18, 2016: RaQualia Receives a Patent Allowance for Acid Pump Antagonist in Korea

                                                                                                                                                                                                                                                                                                      Jan 27, 2016: FDA Approves Takeda’s Dexilant SoluTab (dexlansoprazole)

                                                                                                                                                                                                                                                                                                        Appendix

                                                                                                                                                                                                                                                                                                          Methodology

                                                                                                                                                                                                                                                                                                            Coverage

                                                                                                                                                                                                                                                                                                              Secondary Research

                                                                                                                                                                                                                                                                                                                Primary Research

                                                                                                                                                                                                                                                                                                                  Expert Panel Validation

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                                                                                                                                                                                                                                                                                                                      Reflux Esophagitis (Gastro esophageal Reflux Disease) - Pipeline Review, H1 2019

                                                                                                                                                                                                                                                                                                                      Summary

                                                                                                                                                                                                                                                                                                                      Global Markets Direct's latest Pharmaceutical and Healthcare disease pipeline guide Reflux Esophagitis - Pipeline Review, H1 2019, provides an overview of the Reflux Esophagitis (Gastrointestinal) pipeline landscape.

                                                                                                                                                                                                                                                                                                                      When the liquid content of the stomach refluxes into the oesophagus, that condition is called Gastro esophageal reflux disease (GERD). It is a chronic condition. The symptoms of GERD are nausea, heartburn and vomiting. The predisposing factors include eating large meals, which can cause the Lower Esophageal Sphincter (LES) to open inappropriately, as well as obesity, pregnancy, greasy food and certain drugs.

                                                                                                                                                                                                                                                                                                                      Report Highlights

                                                                                                                                                                                                                                                                                                                      Global Markets Direct's Pharmaceutical and Healthcare latest pipeline guide Reflux Esophagitis - Pipeline Review, H1 2019, provides comprehensive information on the therapeutics under development for Reflux Esophagitis (Gastrointestinal), complete with analysis by stage of development, drug target, mechanism of action (MoA), route of administration (RoA) and molecule type. The guide covers the descriptive pharmacological action of the therapeutics, its complete research and development history and latest news and press releases.

                                                                                                                                                                                                                                                                                                                      The Reflux Esophagitis (Gastrointestinal) pipeline guide also reviews of key players involved in therapeutic development for Reflux Esophagitis (Gastro esophageal Reflux Disease) and features dormant and discontinued projects. The guide covers therapeutics under Development by Companies /Universities /Institutes, the molecules developed by Companies in Phase III, Phase II, Phase I, Preclinical, Discovery and Unknown stages are 6, 6, 6, 4, 1 and 1 respectively.

                                                                                                                                                                                                                                                                                                                      Reflux Esophagitis (Gastrointestinal) pipeline guide helps in identifying and tracking emerging players in the market and their portfolios, enhances decision making capabilities and helps to create effective counter strategies to gain competitive advantage. The guide is built using data and information sourced from Global Markets Direct’s proprietary databases, company/university websites, clinical trial registries, conferences, SEC filings, investor presentations and featured press releases from company/university sites and industry-specific third party sources. Additionally, various dynamic tracking processes ensure that the most recent developments are captured on a real time basis.

                                                                                                                                                                                                                                                                                                                      Note: Certain content / sections in the pipeline guide may be removed or altered based on the availability and relevance of data.

                                                                                                                                                                                                                                                                                                                      Scope

                                                                                                                                                                                                                                                                                                                      - The pipeline guide provides a snapshot of the global therapeutic landscape of Reflux Esophagitis (Gastrointestinal).
                                                                                                                                                                                                                                                                                                                      - The pipeline guide reviews pipeline therapeutics for Reflux Esophagitis (Gastrointestinal) by companies and universities/research institutes based on information derived from company and industry-specific sources.
                                                                                                                                                                                                                                                                                                                      - The pipeline guide covers pipeline products based on several stages of development ranging from pre-registration till discovery and undisclosed stages.
                                                                                                                                                                                                                                                                                                                      - The pipeline guide features descriptive drug profiles for the pipeline products which comprise, product description, descriptive licensing and collaboration details, R&D brief, MoA & other developmental activities.
                                                                                                                                                                                                                                                                                                                      - The pipeline guide reviews key companies involved in Reflux Esophagitis (Gastrointestinal) therapeutics and enlists all their major and minor projects.
                                                                                                                                                                                                                                                                                                                      - The pipeline guide evaluates Reflux Esophagitis (Gastrointestinal) therapeutics based on mechanism of action (MoA), drug target, route of administration (RoA) and molecule type.
                                                                                                                                                                                                                                                                                                                      - The pipeline guide encapsulates all the dormant and discontinued pipeline projects.
                                                                                                                                                                                                                                                                                                                      - The pipeline guide reviews latest news related to pipeline therapeutics for Reflux Esophagitis (Gastrointestinal)

                                                                                                                                                                                                                                                                                                                      Reasons to buy

                                                                                                                                                                                                                                                                                                                      - Procure strategically important competitor information, analysis, and insights to formulate effective R&D strategies.
                                                                                                                                                                                                                                                                                                                      - Recognize emerging players with potentially strong product portfolio and create effective counter-strategies to gain competitive advantage.
                                                                                                                                                                                                                                                                                                                      - Find and recognize significant and varied types of therapeutics under development for Reflux Esophagitis (Gastrointestinal).
                                                                                                                                                                                                                                                                                                                      - Classify potential new clients or partners in the target demographic.
                                                                                                                                                                                                                                                                                                                      - Develop tactical initiatives by understanding the focus areas of leading companies.
                                                                                                                                                                                                                                                                                                                      - Plan mergers and acquisitions meritoriously by identifying key players and it’s most promising pipeline therapeutics.
                                                                                                                                                                                                                                                                                                                      - Formulate corrective measures for pipeline projects by understanding Reflux Esophagitis (Gastrointestinal) pipeline depth and focus of Indication therapeutics.
                                                                                                                                                                                                                                                                                                                      - Develop and design in-licensing and out-licensing strategies by identifying prospective partners with the most attractive projects to enhance and expand business potential and scope.
                                                                                                                                                                                                                                                                                                                      - Adjust the therapeutic portfolio by recognizing discontinued projects and understand from the know-how what drove them from pipeline.

                                                                                                                                                                                                                                                                                                                      Buy now